PhD Degrees Awarded:

Schmidt, Clint, Ph.D., December 2000
Advisor: Matthew Mescher
Thesis: Interleukin-12 as an Adjuvant and Activation Signal for CD8 Positive T Lymphocytes in vivo
Position: Scientist, Dendreon Corporation, Seattle, WA

Reyes, Morayma, Ph.D., August 2001
Advisor: Catherine Verfaillie
Thesis: Purification, Characterization and Differentiation of Multipotent Adult Stem Cell from Post-natal Human Bone Marrow
Position: Assistant Professor, Department of Pathology and Department of Laboratory Medicine, University of Washington, Seattle, WA

Ehst, Ben, Ph.D., December 2001
Advisor: Marc Jenkins
Thesis: Visualization of the Immune Response Against a Skin Graft Expressing a Defined Minor Transplantation Antigen
Position: Assistant Professor, Department of Dermatology, Oregon Health & Science University, Portland, OR

Yarwood, Jeremy, Ph.D., January 2002
Advisor: Pat Schlievert
Thesis: Environmental regulation of virulence gene expression in Staphylococcus aureus
Position: Senior Microbiologist, 3M Center, St. Paul, MN

Reinhardt, R. Lee, Ph.D., April 2002
Advisor: Marc Jenkins
Thesis: In vivo Generation and Migration of Memory CD4 T Cells During the Course of a Primary Immune Response
Position: Postdoctoral Fellow, University of California, San Francisco, CA

Daniels, Mark, Ph.D., April 2002
Advisor: Steve Jameson
Thesis: CD8 Binding to MHC Class I is Influenced by T Cell Maturation and Glycosylation
Position: Assistant Professor, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine

Hodges, Kimberly, Ph.D., July 2002
Advisor: Pat Cleary
Thesis: The a3b1Integrin and CD46 are utilized in Laminin-mediated Invasion of Epithelial Cells by Streptococcus pyogenes
Position: Postdoctoral Fellow, University of Illinois at Chicago, IL

Dylla, Scott, Ph.D., September 2002
Advisor: Catherine Verfaillie
Thesis: The Role of Proline-rich Tyrosine Kinase 2 (Pyk2) and its Hematopoietic Isoform, Pyk2H, in betal-integrin
Signaling in Normal and CML CD34+ Progenitor Cells
Position: Senior Scientist, OncoMed Pharmaceuticals, Mountain View, CA

Waters, Christopher, Ph.D., October 2002
Advisor: Gary Dunny
Thesis: Functional Analysis of Asc10, a Pheromone Inducible Surface Protein of Enterococcus faecalis Involved in Conjugation and Virulence
Position: Postdoctoral Fellow, Princeton University, Princeton, NJ

Paustian, Michael, Ph.D., November 2002
Advisor: Vivek Kapur
Thesis: Identification and Characterization of Iron Acquisition Systems in Pasteurella multocida
Position: Scientist, National Animal Disease Center, Ames, IA

Graham, Robert, Ph.D., November 2002
Advisor: Tim Behrens
Thesis: Localization and Finemapping of Human Systemic Lupus Erythematosus Susceptibility Loci at Chromosome 6p21.3 (The Human Leukocyte Antigen Region) and Chromosome 1q41
Position: Scientist, Genentech, San Francisco, CA

Sweeney, Colin, Ph.D., May 2003
Advisor: R. Scott McIvor
Thesis: Antisense and Drug-resistance Gene Therapy in a Mouse Model of Chronic Myeloid Leukemia
Position: Postdoctoral Fellow, Department of Hematology/Oncology, Case Western Reserve University, Cleveland, OH

Valenzuela, Javier, Ph.D., May 2003
Advisor: Matthew Mescher
Thesis: The Roles of Interleukin-12 as a Third Signal for Clonal Expansion and Cytolytic Function of Naive CD8 T Cells
Position: Postdoctoral Fellow, Moffitt Cancer Center & Research Institute, Tampa, FL

Pribila, Jonathan, Ph.D., May 2003
Advisor: Yoji Shimizu
Thesis: Molecular Mechanisms for the Recruitment andd Retention of Leukocytes in Lymph Nodes
Position: Medical Resident, University of Michigan, Ann Arbor, MI

Hartung, Seth, Ph.D., May 2003
Advisor: R. Scott McIvor
Thesis: Adeno-asociated Virus Vectors Carrying the Human Iduronidase Gene for the Treatment of Mucopolysaccharidosis Type I
Position: Medical Resident, University of Michigan, Ann Arbor, MI

Vanderpool, Carin K, Ph.D., July 2003
Advisor: Sandra Armstrong
Thesis: The Bordetella pertussis Heme Iron Utilization System: Transport and Heme-responsive Gene Regulation
Position: Assistant Professor, University of Illinois

Endrizzi, Bart T., Ph.D., August 2003
Advisor: Steve Jameson
Thesis: The Regulation and Function of KLF-2 in T Cell Biology
Position: Resident, University of Minnesota, Minneapolis, MN

Bonnevier, Jody L., Ph.D., August 2003
Advisor: Daniel Mueller
Thesis: Regulation of Primary CD4 T Cell Cycle Progression
Position: Scientist, R & D Systems, Minneapolis, MN

Morgan, Kelly, Ph.D., August 2003
Advisor: David Largaespada
Thesis: GM-CSF Signaling and GAP Activity in NF1-Associated Leukemia
Position: Postdoctoral fellow, Brigham and Women's Hospital, Boston, MA

Perkins, Keith, Ph.D., November 2003
Advisor: Steve Rice
Thesis: The Activation of a Viral Late Gene by Herpes Simplex Virus Type I
Position: Principal Research Associate, Boston Scientific, Maple Grove, MN

Tomich, Mladen, Ph.D., December 2003
Advisor: Christian Mohr
Thesis: Burkholderia cenocepacia Cable Pili: Identification of the Biosynthetic Locus and Characterization of the Mechanisms of Transcriptional and Posttranscriptional Control
Position: Senior Research Biologist, Merck Research Laboratories, New Jersey

Richards, David, Ph.D., May 2004
Advisor: Daniel Mueller
Thesis: Examining the role of foreign-mHAg-specific CD4(+)T cells and foreign-MHC-specific CD8(+) T cells in the development of Obliterative Airways Disease following transplantation
Position: Postdoctoral Fellow, University of California, Los Angeles, CA

Prlic, Martin, Ph.D., May 2004
Advisor: Stephen Jameson
Thesis: Regulation of lymphocyte homeostasis
Position: Postdoctoral Fellow, University of Washington, Seattle, WA

Linden, Michael, Ph.D., June 2004
Advisor: Brian Van Ness
Thesis: Novel Targeted Deregulation of Apoptotic and Oncogenic Pathways Leads to B-lymphoid Malignancies in Genetically Engineered Mice
Position: Medical Resident, University of Washington, Seattle, WA

Harmala, Lisa, Ph.D., July 2004
Advisor: Christopher Pennell
Thesis: In vivo characterization of the adjuvant effect of mycobacterium tuberculosis Hsp70

Gillespie, Emily, Ph.D., August 2004
Advisor: Tim Behrens
Thesis: Gene expression signatures in peripheral blood define clinical subsets of SLE
Position: Assistant Professor, University of Minnesota, Minneapolis, MN

Vanasek, Tracy, Ph.D., August 2004
Advisor: Daniel Mueller
Thesis: Cell cycle progression regulates in vivo clonal anergy induction

Mayerova, Dita, Ph.D., September 2004
Advisor: Kristin Hogquist
Thesis: Mouse model of autoimmune skin disease
Position: Postdoctoral Fellow, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

Carlson, Corey, Ph.D., November 2004
Advisor: David Largaespada
Thesis: Insertional mutagenesis and tumor modeling in the mouse using the Sleeping Beauty transposon system
Position: Postdoctoral Fellow, Center for Immunology (Jameson lab), University of Minnesota, Minneapolis, MN

Moeller, Stephanie, Ph.D., November 2004
Advisor: Robert Sheaff
Thesis: Re-evaluating the role of the tumor suppressor p27Kip1 in human cancers
Position: 3M Center, St. Paul, MN

Erickson, Heidi, Ph.D., December 2004
Advisor: Christopher Pennell
Thesis: Novel human ribonuclease-based targeted therapeutics for the treatment of T cell acute lymphoblastic leukemia

Maher, Diane, Ph.D., December 2004
Advisor: Peter Southern
Thesis: Transmission of Human Immunodeficiency Cirus Across Human Mucosal Surfaces

Golden, Joseph, Ph.D., March 2005
Advisor: Leslie Schiff
Thesis: Cellular and Viral Determinants of Mammalian Reovirus Uncoating
Position: Postdoctoral Fellow, US Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD

Smith, Jennifer, Ph.D., March 2005
Advisor: Leslie Schiff
Thesis: The regulation of translation in reovirus-infected cells
Position: Postdoctoral Fellow, Harvard Medical School (Peter Howley lab), Boston, MA

Kozlowicz, Briana, Ph.D., March 2005
Advisor: Gary Dunny
Thesis: The molecular mechanism and peptide signaling response of PrgX used to control pheromone-induced conjugative transfer of pCF10
Position: Postdoctoral Fellow, University of Washington, Seattle, WA

Staddon, Jack, Ph.D., May 2005
Advisor: Gary Dunny
Thesis: Identification and Genetic Characterization of a Group II Intron Insertion Site and Origin of Transfer Region in the Enterococcus faecalis plasmic, pCF10
Position: Medical Resident, Loma Linda University, Loma Linda, CA

Pragman, Alexa, Ph.D., May 2005
Advisor: Pat Schlievert
Thesis: Studies on the Staphylococcal Respiratory Response (SrrAB) and its Role in Staphylococcus aureus Virulence Factor Regulation
Position: Medical Resident, University of Chicago, Chicago, IL

Goetz, Christine, Ph.D., June 2005
Advisor: Michael Farrar
Thesis: Regulation of B Lymphocyte Development and Lineage Commitment by the Ras and STAT5 Signaling Pathways
Position: Postdoctoral Fellow, University of North Carolina (Baldwin lab), Chapel Hill, NC

Eckfeldt, Craig, Ph.D., August 2005
Advisor: Catherine Verfaillie
Thesis: Discovery and Functional Analysis of Novel Determinants of Hematopoietic Stem and Progenitor Cell Function
Position: Medical Resident, University of Minnesota, Minneapolis, MN

Magarvey, Nathan, Ph.D., September 2005
Advisor: David Sherman
Thesis: Identification and Accession of Novel Sources of Microbial Natural Product Diversity
Position: Postdoctoral Fellow, Harvard Medical School, Boston, MA

Liu, Jiabin, Ph.D., December 2005
Advisor: Tim Behrens
Thesis: Conserved Systemic Lupus Erythematosus Pathways in Murine Models
Position: Resident, Internal Medicine, Geisinger Medical Center, Danville, PA

Chen, Yuqing, Ph.D., January 2006
Advisor: Gary Dunny
Thesis: Characterization of the Lactococcus lactis Plasmid pRS01 Transfer Region: Expression and Splicing of A group II Intro and Protein-DNA Interactions During Plasmid Transfer
Position: Postdoctoral Fellow, University of Texas, Houston, TX

Kahler, Rachel, Ph.D., February 2006
Advisor: Jennifer Westendorf
Thesis: The Role of Lymphocyte Enhancer-binding Factor 1 (Lef1) in Osteoblast Differentiation
Position: Technology Specialist, Fish and Richardson, LLD, Minneapolis, MN

Lephart, Paul, Ph.D., March 2006
Advisor: Paul Magee
Thesis: Analysis of the Role of the Major Repeat Sequence in Chromosome Dynamics in Candida albicans
Position: Postdoctoral Fellow, American Society for Microbiology, Rochester, NY

Mick, Verity, Ph.D., March 2006
Advisor: Kristin Hogquist
Thesis: The Molecular Events of T Cell Positive Selection in the Thymus

Hau, Heidi, Ph.D., May 2006
Advisor: Paul Bohjanen
Thesis: TTP-mediated Decay of AU-rich containing mRNAs
Position: Postdoctoral fellow, University of Minnesota (Gralnick lab), St. Paul, MN

Chandler, Josephine, Ph.D., May 2006
Advisor: Gary Dunny
Thesis: Control of Endogenous Sex Pheromone Signatling in Enterococcus faecalis
Position: Postdoctoral Fellow, University of Washington (Greenberg lab), Seattle, WA

Hess, Donavon, Ph.D., May 2006
Advisor: Carol Wells
Thesis: Staphylococcus aureua Interactions with the Intestinal Epithelium
Position: Pediatric Surgery Fellow, Women and Children's Hospital of Buffalo, NY

O'Shaughnessy, Matthew, Ph.D., June 2006
Advisor: Bruce Blazar
Thesis: Novel molecular strategies for prevention of graft-versus-host disease by ex vivo tolerance induction
Position: Medical School, University of Minneapolis, Minneapolis, MN

Ogilvie, Rachel, Ph.D., June 2006
Advisor: Paul Bohjanen
Thesis: Tristeteraprolin regulates gene expression in T lymphocytes

Mueller, Kristen, Ph.D., June 2006
Advisor: Yoji Shimizu
Thesis: Regulation of Antigen-Dependent T Cell Interactions with Antigen Presenting Cells and T Cell Activation by the Adapter Protein, ADAP
Position: Postdoctoral Fellow, National Institutes of Health, Bethesda, MD

Hataye, Jason, Ph.D., July 2006
Advisor: Marc Jenkins
Thesis: Cell Competition for Survival and Proliferation Resources Defines the CD4+ T Cell Niche, a Platform for the Maintenance of Antigen Receptor Repertoire Diversity and the Generation of Memory
Position: Medical School, University of Minnesota, Minneapolis, MN

Fortman, Clem, Ph.D., July 2006
Advisor: David Sherman
Thesis: Cloning and Characterization of the Bafilomycin Biosynthesis Pathway from Streptomyces lohii
Position: Postdoctoral Fellow, University of California (Jay Keasling lab), Berkeley, CA

Faivre, Emily, Ph.D., October 2006
Advisor: Carol Lange
Thesis: MAP Kinase Dependence of Progesterone Action in a Breast Cancer Cell Model
Position: Postdoctoral Fellow, University of Minnesota, Minneapolis, MN

Schneider, Lori, Ph.D., December 2006
Advisor: Marc Jenkins
Thesis: Analysis of peptide: MHC II complex production by dendritic cell subsets in skin-draining lymph nodes reveals multiple mechanisms of adjuvant action
Position: Application Scientist, Beckman Coulter, Chaska, MN

Fraser, Katy, Ph.D., January 2007
Advisor: Steve Rice
Thesis: The Aberrant Phosphorylation of RNA Polymerase II During Herpes Simplex Type 1 Infection
Position: Postdoctoral Fellow, Mount Sinai School of Medicine (Peter Palese lab), New York City, NY

Sandau, Michelle, Ph.D., February 2007
Advisor: Steve Jameson
Thesis: The role of interleukin-15 in lymphocyte homeostasis
Position: Postdoctoral Fellow, Washington University, St. Louis, MO

Hammerbeck, Christopher, Ph.D., March 2007
Advisor: Matt Mescher
Thesis: Regulation of IL-7 receptor alpha expression on CD8+ T cells and its role in reversing activation-induced nonresponsiveness
Position: Postdoctoral Fellow, US Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD

Peters, Christopher, Ph.D., May 2007
Advisor: Patrick Mantyh
Thesis: Cellular mechanisms of paclitaxel induced pain and neuropathy
Position: Postdoctoral Fellow, Wake Forest University Baptist Medical Center (James Eisenach lab), Winston-Salem, NC

Vetter, Sara, Ph.D., May 2007
Advisor: Patrick Schlievert
Thesis: Two-component regulation of virulence gene expression in Bacillus anthracis
Position: CDC/NCID Postdoctoral Fellow, Centers for Disease Control (Ken Gage lab), Fort Collins, CO

Agarwal, Pujya, Ph.D., June 2007
Advisor: Matt Mescher
Thesis: Interleukin-12 and Interferon-α/β - mediated Gene Regulation in Programming CD8+ T cell Differentiation
Position: Postdoctoral Fellow, University of Minnesota, Minneapolis, MN

Yarke, Cory, Ph.D., June 2007
Advisor: Dan Mueller
Thesis: Regulation of CD4+ T cell clonal expansion by TCR and CD28 signaling
Position: Medical School, University of Minnesota, Minneapolis, MN

Strain, Anna, Ph.D., June 2007
Advisor: Steve Rice
Thesis: Regulation and export of ICP27 during herpes simplex virus type-1 lytic infection
Position: Postdoctoral Fellow, University of Minnesota, Minneapolis, MN

Burchill, Matt, Ph.D., July 2007
Advisor: Mike Farrar
Thesis: Interleukin-2 receptor-dependent STAT5 activation drives regulatory T cell development
Position: Postdoctoral Fellow, National Jewish Medical Research Center (Philippa Marrack and Ross Kedl labs), Denver, CO

Anderson, Mark, Ph.D., August 2007
Advisor: Sandra Armstrong
Thesis: The Bordetella Bfe system: regulation and function in catechol-mediated iron acquisition
Position: Postdoctoral Fellow, Northwestern University (Hank Seifert lab), Chicago, IL

Popescu, Flavia, Ph.D., September 2007
Advisor: Matt Mescher
Thesis: Targeting CD8 T lymphocyte activation for tumor immunotherapy using peptide antigens and cytokines
Position: Postdoctoral Fellow, University of Minnesota, Minneapolis, MN

Vogtenhuber, Christine, Ph.D., November 2007
Advisor: Bruce Blazar
Thesis: Signaling pathways in regulatory T Cells
Position: Postdoctoral Fellow, University of Minnesota (Blazar lab), Minneapolis, MN

Martin, Amanda, Ph.D., December 2007
Advisor: Yoji Shimizu
Thesis Regulation of T cell migration and the immune response by Phosphoinositide 3-kinase gamma
Position: Bioinformaticist, Intrexon Corporation, Blacksburg, VA

Zhang, Ruan, Ph.D., December 2007
Advisor: Dan Mueller
Thesis: Regulation of CD4+ T cell activation, proliferation and anergy induction by the E3 ligase Cbl-b
Position: Postdoctoral Fellow, University of Pennsylvania (Larry Turka lab), Philadelphia, PA

Woll, Petter, Ph.D., February 2008
Advisor: Dan Kaufman
Thesis: Lympho-hematopoietic development from embryonic stem cells
Position: Postdoctoral Fellow, University of Oxford (Sten Eirik Jacobsen lab), Oxford, England

M.S. Degrees Awarded:

Jiang, Yuehua, M.S., August 1999
Advisor: Catherine Verfaillie
Thesis: Opposing effects of engagement of integrins and stimulation of cytokine receptors on normal human hematopoietic progenitor cell proliferation.
Position: Assistant Professor, Department of Medicine, University of Minnesota, Minneapolis, MN

Zhou, Liang, M.S., September 1999
Advisor: Gary Dunny
Thesis: The Bacterial Group II intron L1.1trB: Regulation of its Expression and the Role in Conjugation
Position: Research Scientist, British Columbia Cancer Agency, Vancouver, BC, Canada

Yue, Shinji, M.S., December 1999
Advisor: Harry Orr
Thesis: Ataxin-1 Nucleic Acid Interaction
Position: Assoc. Product Manager, Reagent Sales; MJ Research, Inc., Waltham, MA

Epler, Jennifer, M.S., May 2000
Advisor: Yoji Shimizu
Thesis: Requirement for ZAP-70 in regulating beta-1 integrin-mediated adhesion in T cells
Position: Research Associate, Genentech, South San Francisco, CA

Parke, Evan, M.S., July 2000
Advisor: Kris Hogquist
Thesis: Antigen presentation in a CD8 T cell-mediated autoimmune disease
Position: Patent attorney, Washington, DC

Gao, Jimin, M.S., July 2000
Advisor: Vivian Bardwell
Thesis: Cloning of Human NOT1 and its Potential Involvement in BCL-6 Function
Position: Enrolled in computer science program, University of Minnesota, Minneapolis, MN

Fink Jason, M.S., October 2000
Advisor: Tucker LeBien
Thesis: Examining the changes in gene expression in B-cell differentiation through differential display
polymerase chain reaction
Position: Research Associate, 3M Company, St. Paul, MN

Vaessen, Ben, M.S., August 2002
Advisor: Catherine Verfaillie
Thesis: Gene Expression Analysis of Multipotent Adult Progenitor Cells
Position: GlaxoSmithKline, Pennsylvania

Asch, Sarah, M.S., August 2003
Advisor: Marc Jenkins
Thesis: Characterizing Antigen Presentation to CD4+ T Cells in Non-lymphoid Tissue
Position: 3M Pharmaceutics, St. Paul, MN

Heggem, Michael, M.S., July 2005
Advisor: Christopher Pennell
Thesis: Heat shock protein immune receptors
Position:

Li, Ying, M. S., May 2007
Advisor: Bruce Walcheck
Thesis: Role of ADAM17 in the ectodomain shedding of the adhesion molecule
Position: Associate Scientist, Schering-Plough Corporation, Kenilworth, NJ

McKelvey, Pam, M.S. January 2008
Advisor: Sandra Armstrong
Thesis: Bordetella pathogenesis and NAD metabolism
Position: