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MICA 8003

Immunity and Immunopathology

Fall Semester, 2018
10:10-11:00 M-Th

Room: MoosT 2-118

Instructors:

Marc Jenkins (Course Director), 6-2715, jenki002@umn.edu, 3-188 WMBB          
Yoji Shimizu, 6-6849, shimi002@umn.edu, 2-110 WMBB
Tanya Freedman, 612-301-8313, tfreedma@umn.edu, 3-190 WMBB
Mike Farrar, 5-0401, farra005@umn.edu, 2-116 WMBB
Dan Mueller, 5-1155, muell002@umn.edu, 3-186 WMBB
Alex Khoruts, 6-1188, khoru001@umn.edu, 3-184 WMBB
Chris Pennell, 5-7138, penne001@umn.edu, 760B CCRB
Erik Peterson, 5-5634, peter899@umn.edu, 2-112 WMBB
Bryce Binstadt, 6-4598, binstadt@umn.edu, 2-114 WMBB
Stephen Jameson, 5-1496, james024@umn.edu, 2-184 WMBB
Thomas Griffith, 4-8269, tgriffit@umn.edu, 3-125 CCRB
Kristin Hogquist, 5-1616, hogqu001@umn.edu, 2-186 WMBB
Sara Hamilton Hart, 5-1626, hamil062@umn.edu, 3-112 WMBB
Geoff Hart, 4-9996, hart0792@umn.edu, 2-103 MRF

https://ay17.moodle.umn.edu/course/view.php?id=15870

Text
Janeway’s Immunobiology.  9th Edition. K. Murphy, et al., Garland Publishing, New York, 2008.

Format
The course will be divided into 14 blocks usually consisting of 4 meetings per block. The first two meetings (Tuesday and Wednesday) will be lectures with assigned textbook chapters. The third meeting (Thursday) will be a journal club-style discussion of a paper that is related to the topic of the block. The paper will be posted on the Moodle site by the instructor. Students are expected to read the assigned paper before class and be ready to discuss it in detail. The instructor will post a problem-solving quiz on the Moodle site shortly after the third meeting of the block. Students will submit their answers back to the instructor through the Moodle site before the beginning of the fourth (Monday) meeting, after which the instructor will present acceptable answers and lead a discussion of alternative answers and their weaknesses. The fourth meeting may will have a summary of the key concepts of the block and may have a group activity designed to reinforce the key concepts. A couple blocks will only have three meetings in which case the first meeting will be a lecture, the second meeting will be a paper discussion and quiz handout and the third meeting will be a discussion of the quiz, summary, and group activity.

Exams
The grade will be based on problem-solving quizzes, one per block, and a fact-based short answer format final exam.

Quiz answers will be limited to 200 words. Answers longer than 200 words will be given a score of 0. Any material available in the scientific literature may be used to answer the quiz questions. However, students are expected to answer their own quiz independently. None of the quiz questions may be discussed with other members of the class until after the quiz. According to criteria discussed during the fourth session, the instructor will grade each quiz, and the graded quiz will be returned to students via the Moodle site.

The final exam will be 2 hours in length, closed book, short answer format, and focused solely on the Key Concepts from each block.

5 points will be given for each quiz for a total of 70 points and 30 points will be given for the final exam. 2 extra credit points will be given for attending all of the course meetings except for one excused absence.

Schedule

Block

Topic

Instructor

Janeway 9th edition
Chapters

Dates

1

Basic Concepts in Immunology

Jenkins

1

Sept. 4, 5# ,6*

2

Innate Immunity: The First Lines of Defense

Binstadt

2

Sept. 11, 12, 13#, 17*

3

The Induced Innate Immune Response

Peterson

3

Sept. 18, 19, 20#, 24*

4

Antigen Recognition by B-cell and T-cell Receptors

Pennell

4

Sept. 25, 26#, 27*

5

Lymphocyte Receptor Signaling

Shimizu/Freedman

7

Oct. 3, 4#, 8*

6

Development of B Lymphocytes

Farrar

5-1 – 5-8
5-12 – 5-16
8-1 – 8-9

Oct. 9, 10, 11#, 15*

7

Development of T Lymphocytes

Hogquist

5-9 – 5-11
5-17 – 5-22
8-10 – 8-28

Oct. 16, 17, 18#, 22*

8

Antigen Presentation to T Lymphocytes

Jenkins

6

Oct. 23, 24, 25#, 29*

9

Mucosal Immunity

Khoruts

12

Oct. 30, 31, Nov.1#, 5*

10

The Humoral Immune Response

Jenkins

10

Nov. 6, 7, 8#, 12*

11

Integrated Dynamics of Innate and Adaptive Immunity

Hamilton

11

Nov. 13,14,15#,19*

12

T-cell-mediated Immunity

Jameson

9

Nov. 20, 21#, 26*

13

Allergy and Allergic Diseases

Hart

14

Nov. 27, 28, 29#, Dec. 3*

14

Autoimmunity and Transplantation

Mueller

15

Dec. 4, 5, 6#, 10*

15

Manipulation of the Immune Response

Griffith

16

Dec. 11, 12, 13#, 17*