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MICA 8003

Immunity and Immunopathology

Fall Semester, 2017
10:10-11:00 M-Th
2-118 Moos Tower

Instructors:
Marc Jenkins (Course Director), 6-2715, jenki002@umn.edu, 3-188 WMBB                    
Yoji Shimizu, 6-6849, shimi002@umn.edu, 2-110 WMBB
Tanya Freedman, 612-301-8313, tfreedma@umn.edu, 3-190 WMBB
Mike Farrar, 5-0401, farra005@umn.edu, 2-116 WMBB .
Dan Mueller, 5-1155, muell002@umn.edu, 3-186 WMBB
Alex Khoruts, 6-1188, khoru001@umn.edu, 3-184 WMBB
Chris Pennell, 5-7138, penne001@umn.edu, 3-135 CCRB
Erik Peterson, 5-5634, peter899@umn.edu, 2-112 WMBB
Bryce Binstadt, 6-4598, binstadt@umn.edu, 2-114 WMBB
Stephen Jameson, 5-1496, james024@umn.edu, 2-184 WMBB
Thomas Griffith, 4-8269, tgriffit@umn.edu, 3-125 CCRB
Kris Hogquist, 5-1616, hogqu001@umn.edu, 2-186 WMBB
Sara Hamilton Hart, hamil062@umn.edu, 2-184 WMBB
Geoff Hart, 4-9996, hart0792@umn.edu, 2-103 MRF

Moodle Site: https://ay17.moodle.umn.edu/course/view.php?id=5019

Text
Janeway’s Immunobiology.  9th Edition. K. Murphy, et al., Garland Publishing, New York, 2008.

Format
The course will be divided into 15 blocks usually consisting of 4 meetings per block. Each block will focus on a chapter from the Janeway textbook. An active learning format will be used for the first two meetings of each block. Students will be expected to have read the chapter from Janeway before the first day of the block. The instructor will spend the first and second days of the block posing questions to the class based on the chapter and gauging their answers anonymously using the Chime In in-class polling system (https://chimein.cla.umn.edu). The instructor will address concepts in class that students are struggling with based on the polling results. By the end of the second day, the questions should be of a problem-solving, thought-provoking variety. The third day of the block will be spent on a journal club-style discussion of a paper that is related to the topic of the block. Students are expected to read the assigned paper before class and be ready to discuss it in detail. The last day of the block will be spent on an in class, closed book exam on the material from the chapter and assigned paper. The entire grade will be based on the 15 block exams. There will be no final exam.

Block Topic Lecturer Book chapters Dates
1 Basic Concepts in Immunology Jenkins 1 Sept. 5, 6, 7, 11
2 The Induced Innate Immune Response Peterson 3 Sept. 12, 13, 14,18
3 Innate Immunity: The First Lines of Defense Binstadt 2 Sept.19, 20, 21, 25
4 Antigen Recognition by B-cell and T-cell Receptors Pennell 4 Sept. 26, 27, 28, Oct. 2
5 Development of B Lymphocytes Farrar 5-1 – 5-8
5-12 – 5-16 8-1 – 8-9
Oct. 3 ,4 ,5, 9
6 Antigen Presentation to T Lymphocytes Jenkins 6 Oct. 10, 11,12, 16
7 Lymphocyte Receptor Signaling Shimizu/Freedman 7 Oct. 17, 18, 19, 23
8 Development of T Lymphocytes Hogquist 5-9 – 5-11
5-17 – 5-22 8-10 – 8-28
Oct. 24, 25, 26, 30
9 T-cell-mediated Immunity Jameson 9 Oct. 31, Nov. 1, 2, 6
10 The Humoral Immune Response Jenkins 10 Nov. 7, 8, 9,13
11 Integrated Dynamics of Innate and Adaptive Immunity Hamilton 11 Nov. 14, 15,16, 20
12 Mucosal Immunity Khoruts 12 Nov. 21, 22, 27
13 Allergy and Allergic Diseases Hart 14 Nov. 28, 29, 30, Dec. 4
14 Autoimmunity and Transplantation Mueller 15 Dec. 5, 6, 7, 11
15 Manipulation of the Immune Response Griffith 16 Dec. 12, 13, 14, 18