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David Largaespada (Course Director), 6-4979, firstname.lastname@example.org, 5-104 MCB
Jaime Modiano (email@example.com)
Timothy Starr (firstname.lastname@example.org)
Carol Lange (email@example.com)
Scott Dehm (firstname.lastname@example.org)
Anindya Bagchi (email@example.com)
Timothy Hallstrom (firstname.lastname@example.org)
Ameeta Kelekar (email@example.com)
Martina Bazzaro (firstname.lastname@example.org)
Kaylee Schwertfeger (email@example.com)
Deepali Sachdev (firstname.lastname@example.org)
Douglas Yee (email@example.com)
Louis Mansky (firstname.lastname@example.org)
The Biology of Cancer. 1st Edition. Robert A. Weinberg, Garland Publishing, New York, 2008.
The course will be divided into 15 blocks consisting of 4 meetings per block. Within each block, the first two meetings will be lectures with assigned textbook chapters and/or journal articles. These lectures will cover key concepts that you will be expected to know for the final exam. Students should expect to spend time outside of class to learn techniques relevant to the assigned reading material. Course materials will be available thru a Moodle course site.
The third meeting will be a journal club-style discussion of a paper that is related to the topic of the block. Students are expected to read the assigned paper before class and be ready to discuss it in detail. Students will be separated into groups the first day of the course and each group will be expected to present part of the paper to the class. The section your group will present will not be assigned until the day of class that you present, therefore, be prepared to discuss any part of the paper. You will have 10 minutes with your group at the beginning of class to prepare your presentation. Presentations will be approximately 5 minutes long. These assigned groups will change three times during the course. Your group assignments will be handed out the first day of class.
The instructor will e-mail a problem-solving quiz to each student shortly after the third meeting. Students will e-mail their answers back to the instructor before the beginning of the fourth meeting, after which the instructor will present acceptable answers and lead a discussion of alternative answers and their weaknesses. The instructor will also summarize the Key Concepts of the block at the fourth meeting.
The exams will include 15 problem-solving quizzes, one per block, and a fact-based short answer format final exam. The quizzes will be e-mailed as MS Word documents by the block instructor to the students shortly after the third meeting of each block. The completed quizzes must be e-mailed by the students back to the block instructor by the beginning of the fourth meeting. Answers must be limited to 250 words. Answers longer than 250 words will be given a score of 0. Note that the block instructor will easily be able to determine if the answer is longer than 250 words using the Word Count function of MS Word. Any material available in the scientific literature may be used to answer the questions. However, students are expected to answer their own quiz independently. None of the quiz questions may be discussed with other members of the class until after the quiz. According to criteria discussed during the fourth session, the instructor will grade each quiz, and the graded quiz will be returned to students via e-mail.
The final exam will be 1 hour in length, closed book, short answer format, and focused solely on the Key Concepts from each block.
Exams - 5 points will be given for each take home quiz for a total of 75 points and 75 points will be given for the final exam.
Participation - 10 points will be given for participation during each block for a total of 150 points. Participation points will be based on attendance, asking/answering questions in class, and group presentations of the journal article on third meeting days. Attendance of all meetings is expected, with an exception for one excused absence during the course (NOT one excused absence per block). Excused absences must be requested from the course director, David Largaespada, when possible, before the missed meeting.
Take Home Quizzes (15 at 5 pts each) – 75 points
Participation Points (15 at 10 pts each block) – 150 points
Final Exam – 75 points
Total Points Available – 300
|1||Introduction to the Course/Cancer Pathology||Largaespada/Modiano||A Groups||Jan 23,24,25,28|
|2||Cancer Genetics: Cancer Viruses, experimental genetics, and the TCGA||Timothy Starr||A Groups||Jan. 30, 31, Feb. 1, 4|
|3||Cell Signaling I: The cytoplasm (GF receptors, G-protein coupled receptors)||Carol Lange||A Groups||Feb. 6, 7, 8, 11|
|4||Cell Signaling II: RAS, SRC, P13K, SHH, WNT, TGFbeta||David Largaespada||A Groups||Feb. 13, 14, 15, 18|
|5||Cell Signaling III: The nucleus (steroid hormone receptors, Fos/Jun, JAK-STAT)||Scott Dehm||A Groups||Feb. 20, 21, 22, 25|
|6||Tumor suppressor genes; Genome Instability; Stem cells||David Largaespada/Anindya Bagchi||B Groups||Feb. 27, 28, March 1, 4|
|7||RB/ Cell Cycle/P53||Tim Hallstrom||B Groups||March 6, 7, 8, 11|
|8||Apoptosis||Ameeta Kelekar||B Groups||March 13, 14, 15, 25|
|9||Autophagy/Metabolism||Ameeta Kelekar||B Groups||March 27, 28, 29, April 1|
|10||Cellular Immortalization; Cancer Stem Cells||Anindya Bagchi||B Groups||April 3, 4, 5, 8|
|11||Angiogenesis||Martina Bazzaro||C Groups||April 10, 11, 12, 15|
|12||Tumor Microenvironment /Invasion & Metastasis; Integrins||Kaylee Schwertfeger||C Groups||April 17, 18, 19, 22|
|13||Cancer Therapy I: Small molecules and Targeted Therapy||Deepali Sachdev/Doug Yee||C Groups||April 24, 25, 26, 29|
|14||Cancer Therapy II: Tumor Immunology & Immune Therapies||Pending||C Groups||May 1, 2, 3, 6|
|15||Human Cancer and Microbes: Bacteria and Viruses||Lou Mansky/David Largaespada||C Groups||May 8, 9, 10|