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MICA 8371

Mucosal Immunobiology

Fall Semester, 2013
Monday & Wednesday, 3:00-4:30
17-165 Moos Tower

OBIO/MICaB/CMB 8371
I.  Instructor information
Instructor's name: Mark Herzberg and Massimo Costalonga, course coordinators
Office location: 17-164/ 18-226 Moos Tower, Minneapolis
Office hours: by arrangement
Phone number(s): 625-8404/626-2466
Fax number: 626-2651
Email address: mcherzb@umn.edu / costa0022umn.edu
Preferred method of contact: E-mail

II.  Course Details
Number of credits: 3
Can course be repeated: No

Day(s) of week, time, room location of course: Monday, Wednesday, 3:00-4:30 pm, 17-165 Moos Tower, Minneapolis

Description of class meetings that occur outside of above: No scheduled outside activities.

Term(s) offered:  Fall semester annually.
Course prerequisites: MICA 8003 (Immunity and Immunopathology) or equivalent.
Brief description of the course: Course aims to provide strong fundamental knowledge about the mechanisms of mucosal immunity in humans and animals, including host immune processes at mucosal epithelial surfaces, innate and adaptive immunity, interactions and responses of various mucosal tissues to pathogens and approaches to target protective vaccination to mucosal tissues. Classes are organized by topic with a supportive textbook (strongly recommended), review papers and research reports from the scientific literature.  For many topics, an expert faculty instructor will present a general overview lecture. Other sessions will require journal club-style, student-led review of recent original research in the topic area and engaged discussion by the others in the class.  Students will also prepare and present an original research proposal that is relevant to the topics covered in the class.  A final exam will be required for students seeking academic credit.

Course goal(s): The major goals for this course are to provide fundamental knowledge of immunobiological processes at the moist epithelial surfaces of humans and animals, develop an understanding of cutting edge research on major issues in the field, and engage with a novel research question of the student’s choosing.

Objectives: The course assists participants in their efforts to:

  • Comprehend the significance and special features of mucosal immunobiology.
  • Grasp the fundamental biological principles that operate in immune protection of mucosal tissues.
  • Communicate effectively regarding advanced, current scientific concepts in the field.
  • Understand and interpret current literature in the field.


Expectations
: Students are expected to gain an advanced understanding of the specialized processes and mechanisms that are central to maintenance of health and resistance to disease at mucosal surfaces, an appreciation of major research questions in the field, and the confidence to discuss and debate with colleagues.

SLO:  Have acquired skills for effective scientific citizenship and life-long learning.
            Assignments or coursework related to the SLO: Students apply the learning objectives to problems presented in published materials and as presented by instructors.
            How is the related coursework assessed: Coursework is assessed by examination, written assignments and oral presentations and class participation as assessed by the instructors.

III.  Additional Information
Required and recommended materials and the location of the materials: A textbook is highly recommended: Phillip Smith, Thomas MacDonald, Richard Blumberg, Principles of Mucosal Immunology. Garland Science, 2012. Faculty lectures, review articles, and required journal papers are posted on the course website (Moodle).

Attendance requirements: Must attend at least 80% of classes.

Assignments (include policy on late assignments): Students are responsible for attending regular lectures and student presentations, presenting and leading analysis/discussions of review and primary research papers, developing and presenting a research proposal on a topic relevant to the course, submitting the proposal in written form and presenting it orally. Late assignments are treated as missed.

Examinations (include statement on making up exams): Final exam is required for academic credit. Make-up exam is not available. 

Grading (include weight of assignments in grade):
Grading is A-F and based on:
Class participation and presentations, 30%
Term paper/written proposal, 40%
Final exam, 30%
.
Supplementary Information: This course is cross-listed as OBIO 8371, CMB 8371, and MICA8371.

The following policies apply to all courses at the University of Minnesota:
Grading and Transcripts: Twin Cities, Morris, Rochester.
Teaching and Learning: Instructor and Unit Responsibilities: Twin Cities, Morris, Rochester).
Teaching and Learning: Student Responsibilities (Twin Cities, Morris, Rochester)
Makeup Work for Legitimate Absences: Twin Cities, Morris, Rochester
Use of Personal Electronic Devices in the Classroom: Twin Cities, Morris, Rochester
Appropriate Student Use of Class Notes and Course Materials: Twin Cities, Morris, Rochester
Student Conduct Code
Sexual Harassment
Diversity, Equal Employment Opportunity, and Affirmative Action
Availability of Mental Health Services


 

 

 

Textbook is highly recommended.
(see relevant chapters below in class schedule):
Phillip Smith, Thomas MacDonald, Richard Blumberg, Principles of Mucosal Immunology. Garland Science, 2012.

 

Fall 2013
3 cr.

Course coordinators:

Massimo Costalonga and Mark C. Herzberg

x6-2466; costa002@umn.edu
x5-8404; mcherzb@umn.edu

 

Date

Topic

Instructor

Contact/
Other information

9/4,9

Overview of the Mucosal Immune System Structure (Chap. 1) and Phylogeny (Chap. 2)

Class does not meet; do readings individually

 

costa002@umn.edu

9/11

Compartmentalization of the Mucosal Immune System (Chap. 3)

Massimo Costalonga

 

9/16

Secreted Innate Effectors (Chap. 4) and immune Function of Epithelial Cells (Chap. 5)

Michael Murtaugh, Mark Herzberg

mcherzb@umn.edu

9/18

Mucosal B cells (Chap. 8) and Secretory Immunoglobulins (Chap. 9)

Michael Murtaugh

murta001@umn.edu

9/23

Intraepithelial (Chap. 6) and Lamina Propria Lymphocytes (Chap. 7)

Massimo Costalonga

costa002@umn.edu

9/25

Dendritic cells (Chap. 10) and Macrophage (Chapt 11)

Nathan Welty

welt0123@umn.edu

9/30

Journal club-M Cells and Follicle-Associated Epithelium (Chap. 13)

Mark Herzberg

 

10/2

Microbiota and T helper cell development

Alex Khoruts

 

10/7

Journal Club-Lymphocyte Trafficking (Chap. 14)

Herzberg

 

10/9

Mucosal Tolerance (Chap. 15)

 (?)

Proposal abstract due to Dr. Costalonga/Dr. Herzberg

10/14

Journal Club-Tolerance

 (?)

 

10/16

Microbe-Associated Molecular Patterns, Receptors and Signaling (Chap. 16)

Patrick Arndt/ Erik Peterson-inflammasome

 

10/21

Commensal Microbiota (Chap. 17)

Richard Isaacson

 

10/23

Nose, Airways, Lungs and Oral Cavity (Chap. 20 & 21)

Costalonga/ Patrick Arndt/
Bryan Williams

 

10/28

Journal Club-The Gladiators: Battles between Commensal and Pathogens

Isaacson/Arndt/Williams

 

10/30

Enteric pathogens (Chap. 23 & 24), Celiac Disease, (Chap. 28), Inflammatory Bowel Disease (Chap. 31), Food Sensitivities (Chap. 32)

Alex Khoruts/
Isaacson/
Sreevatsan

 

11/4

Mucosal Basophils, Mast cells and Eosinophils (Chap. 11) with Journal Club

Sriram Rao

 

11/ 6, 11

Journal Club-Viral infections
 (Chap. 25), including
influenza, HSV-1/2, CMV, HHV-8

Yuying Liang/ Mark Schleiss/ Shane McAllister

 

11/13

Journal Club-Infection-Driven Periodontal Disease (Chap. 26)

Costalonga/
Herzberg

 

11/18

Open date-student presentations: preliminary overview of proposals (?)

 

 

11/20

Vaccine Strategies (Chap. 27)

Murtaugh/ Yuying Liang
/Pam Skinner

 

11/25, 27

Thanksgiving week

Class does not meet.

 

12/02, 04

Vaccine Strategies (Chap. 27)

Murtaugh/ Yuying Liang/Pam Skinner

 

12/09, 11, (16*)

15 min STUDENT PRESENTATIONS

All

 

12/18

Final exam

 

Final paper due–submit on Moodle & email to Dr. Costalonga/Dr. Herzberg

Confirmed

*12/16 and 12/18 is during finals week and session will be held if needed. 

VETERINARY

Michael P Murtaugh, PhD <murta001@umn.edu>

Appointment:

Professor
Veterinary Biosciences

                        205 Vet Sci
1971 Commonwealth Ave
St Paul, MN 55108
651-484-5451

Jaime Modiano <modiano@umn.edu>

Appointment:

Professor
Veterinary Clinical Sciences
UMN Twin Cities

Mark S Rutherford <ruthe003@umn.edu>

Appointment:

Associate Professor
Veterinary Biosciences (office: Veterinary and Biomedical Sciences)
UMN Twin Cities

David R Brown <brown013@umn.edu>

Appointment:

Vice Chair
Veterinary Biosciences (office: Veterinary and Biomedical Sciences)
UMN Twin Cities

Pamela J Skinner <skinn002@umn.edu>

Appointment:

Associate Professor
Veterinary Biosciences (office: Veterinary and Biomedical Sciences)
UMN Twin Cities

Richard Isaacson <isaac015@umn.edu>

Appointment:

Professor
Veterinary Biosciences (office: Veterinary and Biomedical Sciences)
UMN Twin Cities

Srinand Sreevatsan <sreev001@umn.edu>

Appointment:

Associate Professor
Veterinary Population Medicine
UMN Twin Cities

Lucy Vulchanova <vulch001@umn.edu>

Appointment:

Assistant Professor
Veterinary Biosciences (office: Veterinary and Biomedical Sciences)
UMN Twin Cities

Bruce K Walcheck <walch003@umn.edu>

Appointment:

Professor
Veterinary Biosciences (office: Veterinary and Biomedical Sciences)
UMN Twin Cities


MICaB

Patrick G. Arndt, M.D. <arndt108@umn.edu>
Associate Professor
Medicine
Pulmonary/Critical Care Med
612-626-4871 office

Marc Jenkins, PhD <jenki002@umn.edu>
Microbiology/Ctr for Immunology
WMBB
2641C (Campus Delivery Code)
2101 6th St SE
Minneapolis, MN 55455
612-626-2715

Dan Kaplan, M.D., Ph.D. <dankaplan@umn.edu>
Assistant Professor
Department of Dermatology
612-626-9400 office
612-624-5664 lab
Lab website: http://www.kaplanlab.umn.edu/

Alex Khoruts, MD  <khoru001@umn.edu>
Associate Professor
Medicine
Immunology
BSBE Bldg
312 Church St SE
Minneapolis, MN 55455
612-625-8999
Cell: 763-546-9006

David Masopust, Ph.D. <masopust@umn.edu>
Assistant Professor
Department of Microbiology
612-625-4666 - office
612-625-5869 - lab
Lab web site: http://masopustvezyslabs.umn.edu/

Erik J. Peterson, MD <peter899@umn.edu>
Associate Professor
Medicine Rheumatology
2-112 MBB
612-625-5634
612-625-0661

Vaiva Vezys, Ph.D. <vvezys@umn.edu>
Assistant Professor
Department of Microbiology
612-625-4650 - office
612-625-5869 - lab
Lab web site: http://masopustvezyslabs.umn.edu/

Bryan J Williams MD PhD <bjwillia@umn.edu>

Assistant Professor
Medicine/PACC
350 VCRC
401 E River Parkway
Minneapolis, MN 55455
612-624-0999

Dental School
Massimo Costalonga, DMD, PhD <costa002@umn.edu>
Associate Professor
Preventive Sciences - Periodontology
18-226 Moos Tower
515 Delaware St SE
Minneapolis, MN 55455
612-626-2466

Joel Rudney, PhD <jrudney@umn.edu>
Professor
Diagnostic and Biological Sciences
Diagnostic and Biological Sciences
17-238A Moos T
515 Delaware St SE
Minneapolis, MN 55455
612-624-7199

Sven Gorr, PhD <sugorr@umn.edu>
Associate Dean
School of Dentistry
Room 18-154 Moos Tower
515 Delaware St SE
Minneapolis, MN 55455
612-626-5728

Mark Herzberg, DDS/PhD mcherzb@umn.edu
Professor
Diagnostic/Biological Sciences
17-164 Moos Tower
515 Delaware St SE
Minneapolis, MN 55455
612-625-8404

Louis M. Mansky PhD mansky@umn.edu
Professor
Diagnostic/Biological Sciences (office: Institute for Molecular Virology)
Room 18-256B MoosT
515 Delaware St S E
Minneapolis, MN 55455
612-626-5525

Medical School
Shane McAllister, MD smcallis@umn.edu
Assistant Professor
Pediatrics
Center for Infectious Disease
LRB/MTRF
2873C (Campus Delivery Code)
2001 6th St SE

Mark Schleiss, MD schleiss@umn.edu
Professor
Pediatrics (office: Pediatric Infectious Diseases)
Pediatric Infectious Diseases
Room 3-214 MTRF
2001 6th Street SE
Minneapolis, MN 55455
612-626-9913
612-624-1112