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Danhua (Flora) Fan
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E-mail: fanx0038@umn.edu
Thesis Advisor: Peter Bitterman
Year entered: 2003
Degrees received:
B.S., Biochemistry, Nankai University, 2000;
M.S., Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 2003
Honors and Awards:
- Best poster award for the 2005 Bioinformatics Symposium, April 26, 2005
- Digital technology initiative program grant, May 6, 2005
- MICaB Travel Award, Spring 2007
Thesis research:
Translational regulation has two mechanisms as shown by 2 distingished polyribosomal tracing. In one type of regulation, the transcript binds more number of polyribosome in one condition compared with the other condition; while in the other type of regulation, the transcript is polyribosome free in one condition and binds to polyribosome in the other condition. My research tries to identify the transcripts that follow these patterns in breast cancer cell lines and understand the underlying mechanisms for these two different regulations. Sequence elements in mRNA have been found to play an important role in post-transcriptional regulation of gene expression. I am also trying to develop tools to identify mRNA elements in untranslated sequence regions of unaligned transcripts in a genome-wide study of coordinately regulated transcripts.
Publications:
- Larsson, O., Perlman, D.M., Fan, D., Reilly, C., Peterson, M., Dahlgren, C., Liang, X., Li, S., Polunovsky, V.A., Wahlestedt, C. and Bitterman, P.B. 2006. Translational Control of Cell Viability: A genome-wide study of eIF4E mediated apoptosis resistance. Nucleic Acids Res. 2006;34(16):4375-86.
- Irina A. Vlasova, Nuzha M. Tahoe, Danhua Fan, Ola Larsson, Jayprakash Vasdewani, George Karypis, Peter Bitterman, and Paul R. Bohjanen. GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1. submitted
- Danhua Fan, Pete B. Bitterman and Ola Larsson. Identification of Post-Transcriptional Regulatory RNA Elements in Subsets of Unaligned Transcripts: Comparison and Integration of Current Computational Methods. submitted
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