MICaB Graduate Program
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B.S., University of Minnesota, Duluth, Minneapolis, MN, 2005
Honors and Awards:
- Cancer Biology Training Grant T32
- F31 Ruth L. Kirschstein National Research Service Award - National Cancer Institute,
- MICaB Travel Award (Spring 2015)
Cancer cells alter their metabolic pathways to divert nutrients into pathways that generate biomass. Although much of what we know about cellular metabolism was discovered half a century ago, recent technologies have allowed us to discover novel critical pathways involved in the proliferative process. These pathways represent key therapeutic vulnerabilities in cancers across the spectrum. My research is focused on identifying new pathways involved in supporting proliferation in a variety of cancer cell types and in immune cells where the proliferative response can dictate the response to infection.
- Yan Y, Hanse EA, Stedman K, Benson JM, Lowman XH, Subramanian S, Kelekar A. 2016. Transcription factor C/EBP-β induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells. Cell Death Differ. Jul;23(7):1232-42.
- Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr. 2016. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 165(2):497
- Karim CB, Espinoza-Fonseca LM, James ZM, Hanse EA, Gaynes JS, Thomas DD, Kelekar A. 2015. Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. Sci Rep. 5:14557.
- Xie C., Lu H., Nomura A., Hanse E.A., Forster C.L., Parker J.B., Linden M.A., Karasch C. and Hallstrom T.C. 2015. Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. Mol. Cancer 14(1):93.