University of Minnesota
MICaB Graduate Program
http://micab.umn.edu
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Current Students

Irey
Emily Irey

E-mail:ireyx004@umn.edu

Thesis Advisor: Kaylee Schwertfeger

Year entered: 2015

Degrees received:
B.A., University of Minnesota, Morris, MN 2014

Honors:

  • Dean's Distinguished Graduate Fellowship, 2015-2020
  • Poster presentation at American Indian Science and Engineering Society, November 2015
  • AISES Travel Scholarship


Thesis Research:

Despite advances in therapies for breast cancer, this disease still remains a significant cause of mortality in women. Much interest surrounds the development of systemic novel targeted therapeutics, however, little is known about how these drugs affect the surrounding non-tumor cells within the tumor microenvironment. Understanding how systemically-delivered breast cancer-targeted therapies interact with non-tumor cells such as infiltrating macrophages is necessary for elucidating how cells become drug resistant and for developing more effective and durable therapies in cancer patients.

The Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling pathway is activated in breast cancer and when hyperactive, can influence uncontrollable proliferation and inflammation. New therapies aim to inhibit JAK/STAT signaling components to turn off the “switch” in tumors signaling for growth and proliferation.  My research will involve looking at how inhibitors of the JAK/STAT pathway affect the tumor microenvironment. We hypothesize that although, inhibition of the JAK/STAT pathway may act on the primary tumor directly, the inhibitor alters a delicate balance in the microenvironment that pushes infiltrating macrophages from an anti-tumor immune response to a pro-inflammatory and thus, pro-tumorigenic response. I aim to delineate the signaling components responsible for creating this shift from tumor-hostile to tumor-friendly, as well as, developing combinatorial therapeutic strategies to target the tumor itself, as well as maintaining an anti-tumor response within the surrounding microenvironment.