University of Minnesota
MICaB Graduate Program
http://micab.umn.edu
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Current Students

McCann
Jennifer McCann

E-mail:mccan121@umn.edu

Thesis Advisor: Reuben Harris

Year entered: 2014

Degrees received:
B.S., University of Utah, Salt Lake City, UT, 2011

Honors and Awards:

  • NSF Graduate Fellowship, 2015-present
  • AACR Scholar-in-Training Award – Supported by Susan G. Komen (SABCS 2015)


Research:
The APOBEC3 family of cytidine deaminases is exploited during the innate immune response to repress infections by deaminating viral single stranded DNA. However, recent work has shown that APOBEC3 enzymes can become misregulated and contribute to cancer mutagenesis. One family member in particular, A3B (APOBEC3B), causes mutations in many cancer types. A3B is not expressed in normal tissues but becomes upregulated in malignant tissues as well as virally infected cells. Thus, A3B is beneficial by suppressing viral infection, but its misregulation can cause collateral damage to the host genome. Using a combination of molecular and genetic approaches, my goal is to elucidate the mechanism through which A3B gains access to the host genome and ultimately how A3B activity is regulated.

Publications:

  • Leonard, B., McCann, J., Starrett, G., Kosyakovsky, L., Molan, A., Burns, M., McDougle, R., Parker, P., Brown, W., Harris, R. 2015. “The PKC-NFκB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers”. Cancer Research. 75(21):4538-47.