University of Minnesota
MICaB Graduate Program
http://micab.umn.edu
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Current Students

Naumann
Jordan Naumann

Email:jnaumann@umn.edu

Thesis Advisor:

Year entered: 2017

Degrees received:
B.S., Minnesota State University, Mankato, MN, 2010
M.S., University of Northern Iowa, Cedar Falls, IA , 2014

Research:

The APOBEC3 family of cytidine deaminases are anti-viral restriction factors that exhibit activity against a wide variety of reverse-transcribing retroviruses and retroelements by converting cytosines-to-uracils in single stranded DNA. While APOBEC3 enzymes are a critical component of the innate immune system, recent studies indicate that APOBEC3B, which is upregulated in several different cancer types, is a major source of mutation in primary and metastatic tumors. Tumors that express high levels of APOBEC3B generally have enhanced mutational burdens. I am investigating the possible relationship between APOBEC3B mutation, neoepitope generation, and responses to immunotherapy.