Main navigation | Main content
B.S., University of Vermont, Burlington, VT, 2012
Our lab studies the bacterial pathogen Mycobacterium tuberculosis (Mtb), which is the causative agent of tuberculosis. Mtb is capable of persisting in a latent state within immune-competent individuals, and then re-activating to cause active disease and promote transmission. We are interested in determining bacterial factors responsible for this persistence within the human host despite a competent immune response. It has recently been described that Mtb releases antigenic membrane vesicles, but little is known about how these vesicles are produced or what role they play during infection. We have recently obtained evidence supporting that the release of membrane vesicles is a regulated process. My thesis research will seek to better understand this regulation, as well as the role of vesicles during infection.