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MICaB Faculty

Anindya Bagchi
Anindya Bagchi, Ph.D.

Assistant Professor

Masonic Cancer Center and Department of Genetics, Cell Biology and Development

Jawaharlal Nehru University, India, 2001, Ph.D.

612-625-7598 office
612-625-2132 lab

E-mail:bagch005@umn.edu


Research Interests:

Chromatin, CHD5, Chromosome Engineering, Tumor Suppressor, Schizophrenia

1. We are interested in developing functional genetic models of human diseases, namely cancer and schizophrenia. We are particularly interested in understanding the effect of the genomic structural variants associated with these diseases. Recurrent genomic deletions and amplifications have been a hallmark of many cancers. Similarly, the role of genomic copy number variation (CNV) in neurological diseases is coming under sharp focus after being implicated in a number of genome wide association studies. We use chromosome engineering, a technique that combines Cre/loxP and gene targeting in mouse embryonic stem (ES) cells to create genetically enginnered mouse models mirroring these aberrations.

2. We are interested in understanding the role of the chromatin in cancer. How the chromatin remodels in response to cellular cues is pivotal to the final outcome of the cell. Importantly, chromatin influences cellular differentiation. The malignant transformation of cell is partly due to improper cellular differentiation and collapse of a proper chromatin remodeling machinery, leading to activation of agents of transformation. Recently we identified Chromodomain helicase DNA binding protein (CHD5), a chromatin remodeling gene, as a tumor suppressor. CHD5 is located in Hu 1p36.3, a locus frequently deleted in many cancers. We are now investigating the molecular mechanism of tumor suppression by CHD5.

Selected Recent Publications:

  • Sarver AL, Murray CD, Temiz NA, Tseng YY and Bagchi A. 2016. MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer. Cell Cycle, (In Press)
  • Tseng YY, Moriarity BS, Gong W, Kawakami H, Tiwari A, Akiyama R., Ronning P, Reuland B, Guenther K, Beadnell TC, Essig, J., Otto GM, O‚ÄôSullivan MG, Largaespada DA, Schwertfeger KL, Marahrens Y, Kawakami Y and Bagchi A. 2014. PVT1-dependence in cancer with MYC copy-number-increase. Nature, 512:82-86.
  • Chen S., Bohrer L.R., Rai A.N., Pan Y., Gan L., Zhou X., Bagchi A., Simon J.A. and Huang H. 2010. Cyclin-dependent kinases regulate epigenetic gene silencing via phosphorylation of EZH2. Nature Cell Biology 12:1108-1114.
  • Stark KL*, Xu B*, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA. 2008. Altered brain microRNA biogenesis in mice deficient for the 22q11 region contributes to behavioral and neuronal development deficits. Nature Genetics, ; 40:751-760. (* Equal authorship).
  • Bagchi A, Mills AA. The Quest for the 1p36 Tumor Suppressor. 2008. Cancer Research, 68:2551-2556.
  • Bagchi A, Papazoglu C, Wu Y, Capurso D, Brodt M, Francis D, Bredel M, Vogel H, Mills AA. 2007. CHD5 is a tumor suppressor at Human 1p36. Cell, 128:459-475.