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Anindya Bagchi, Ph.D.
Assistant Professor
Masonic Cancer Center and Department of Genetics,
Cell Biology and Development
Jawaharlal Nehru University, India, 2001, Ph.D.
bagch005@umn.edu
612-625-7598 office
612-625-2132 lab
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Research Interests:
Chromatin, CHD5, Chromosome Engineering, Tumor Suppressor,
Schizophrenia
1. We are interested in developing functional genetic models
of human diseases, namely cancer and schizophrenia. We are
particularly interested in understanding the effect of the
genomic structural variants associated with these diseases.
Recurrent genomic deletions and amplifications have been a
hallmark of many cancers. Similarly, the role of genomic copy
number variation (CNV) in neurological diseases is coming
under sharp focus after being implicated in a number of genome
wide association studies. We use chromosome engineering, a
technique that combines Cre/loxP and gene targeting in mouse
embryonic stem (ES) cells to create genetically enginnered
mouse models mirroring these aberrations.
2. We are interested in understanding the role of the chromatin
in cancer. How the chromatin remodels in response to cellular
cues is pivotal to the final outcome of the cell. Importantly,
chromatin influences cellular differentiation. The malignant
transformation of cell is partly due to improper cellular
differentiation and collapse of a proper chromatin remodeling
machinery, leading to activation of agents of transformation.
Recently we identified Chromodomain helicase DNA binding protein
(CHD5), a chromatin remodeling gene, as a tumor suppressor.
CHD5 is located in Hu 1p36.3, a locus frequently deleted in
many cancers. We are now investigating the molecular mechanism
of tumor suppression by CHD5.
Selected Recent Publications:
- Stark KL*, Xu B*, Bagchi A, Lai WS, Liu H, Hsu R, Wan
X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA. 2008.
Altered brain microRNA biogenesis in mice deficient for
the 22q11 region contributes to behavioral and neuronal
development deficits. Nature
Genetics, ; 40:751-760. (* Equal authorship).
- Bagchi A, Papazoglu C, Wu Y, Capurso D, Brodt M, Francis
D, Bredel M, Vogel H, Mills AA. 2007. CHD5 is a tumor suppressor
at Human 1p36. Cell,
128:459-475.
- Mandal P, Bagchi A, Bhattacharya A, Bhattacharya S. 2004.
An Entamoeba histolytica LINE/SINE Pair Inserts at Common
Target Sites Cleaved by the Restriction Enzyme-Like LINE-Encoded
Endonuclease. Euk.
Cell, 3:170-179.
- Sharma R*, Bagchi A*, Bhattacharya S, Bhattacharya A.
2001. Characterization of a Retrotransposon like element
in Entamoeba histolytica. Mol.
Biochem.Parasitol, 116:45-53. (*Equal authorship).
- Sharma R, Bagchi A, Bhattacharya S, Bhattacharya A. 2000.
Characterization of Retrotransposon-like repetitive DNA
in Entamoeba histolytica. Arch
Med Res. 31(4 Suppl):S266-8.
- Bagchi A, Bhattacharya A, Bhattacharya S. 1999. Lack of
a chromosomal copy of the circular rDNA plasmid of Entamoeba
histolytica. Int
J Parasitol; 29:1775-1783.
Last modified on: August 4, 2009 |
