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Vivian J. Bardwell, Ph.D.
Associate Professor
Department of Genetics, Cell Biology and Development
University of Wisconsin-Madison, 1990, Ph.D.
bardw001@umn.edu
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Research Interests:
Cancer biology
One interest of the lab is the role of transcription factors
in cancer, in particular a family of transcription factors
that appear to be involved in both cancer and normal development.
These proteins contain a zinc finger DNA binding domain. They
also have a POZ domain, a motif that mediates protein-protein
interactions among family member and transcriptional repression.
The protein that we work with is BCL-6. Inappropriate expression
of BCL-6 is associated with diffuse large cell lymphoma. We
are interested in determining what genes this repressor regulates
and how it carries out repression. A second project involves
the gene Dmrt1, which is likely to play a role in mammalian
sex determination. The protein, DMRT1, is also a transcription
factor and we are interested in how it regulates transcription,
how it fits into the sex determination pathway.
Selected Recent Publications:
- Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. 2006. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol. 26(18):6880-9.
- Chevallier, N., Corcoran, C.M., Lennon, C., Haijek, E., Chadburn, A., Bardwell, V.J., Licht, J.D., Melnick, A. 2004. The ETO Protein of t(8;21) AML is a Corepressor for the Bcl-6 B cell Lymphoma Oncoprotein. Blood 103(4):1454-63.
- Kim, S., Kettlewell, J.R., Anderson, R.C., Bardwell, V.J. and Zarkower, D. 2003. Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad. Mechanisms of Development. 3(1):77-82.
- Melnick, A., Carlile, G., Ahmad, K.F., Kiang, C.L., Corcoran, C., Bardwell, V., Prive, G.G. and Licht, J.D. 2002. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Mol. Cell. Biol. 22:1804-18.
- Raymond, C.S., Murphy, M, O'Sullivan, M.G., Bardwell, V.J. and Zarkower, D. 2000. Dmrt1 a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes and Development 14:2587-2595.
- Huynh, K.D. and Bardwell, V.J. 1998. The BCL-6 POZ domain and
other POZ domains interact with the co-repressors N-CoR
and SMRT. Oncogene
17:2473-2483.
Last updated: October 24, 2006 |
