University of Minnesota
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MICaB Faculty

Cichocki
Frank Cichocki, Ph.D.

Assistant Professor

Department of Medicine

University of Minnesota, Minneapolis, 2010, Ph.D.

612-624-7662 office

E-mail:cich0040@umn.edu


Research Interests:

Human NK cell biology

Our group has a long-standing interest in the development and differentiation of human natural killer (NK) cells. NK cells represent a lineage of cytotoxic lymphocytes that play key roles in immunosurveillance of virally infected and transformed cells. Our current work is focused on the molecular mechanisms controlling the differentiation, expansion, signaling and function of unique, heterogeneous subsets of adaptive NK cells that arise in response to cytomegalovirus (CMV) infection in healthy individuals and CMV reactivation in hematopoietic cell transplant (HCT) recipients. Our group is also actively exploring pathways important for the efficient generation of highly functional NK cells from induced pluripotent stem cells

Selected Recent Publications:

  • Cichocki F, Valamehr B, Bjordahl R, Zhang B, Rezner B, Rogers P, Gaidarova S, Moreno SK, Tuininga K, Dougherty P, McCullar V, Howard P, Sarhan D, Taras E, Schlums H, Abbot SE, Shoemaker D, Bryceson YT, Blazar BR, Wolchko S, Cooley S, Miller JS. GSK 3 inhibition drives maturation of NK cells and enhances their antitumor activity. Cancer Res. 2017;[Epub ahead of print]
  • Sarhan D, Cichocki F, Zhang B, Yingst A, Spellman SR, Cooley S, Verneris MR, Blazar BR, Miller JS. Adaptive NK Cells with Low TIGIT Expression are Inherently Resistant to Myeloid-Derived Suppressor Cells. Cancer Res. 2016;76(19):5696-5706.
  • Tesi B, Schlums H, Cichocki F, Bryceson YT. Epigenetic Regulation of Adaptive NK Cell Diversification. Trends Immunol. 2016;37(7):451-461.
  • Cichocki F, Schlums H, Theorell J, Tesi B, Miller JS, Ljunggren HG, Bryceson YT. Diversification and Functional Specialization of Human NK Cell Subsets. Curr Top Microbiol Immunol. 2016;395:63-94.
  • Cichocki F, Cooley S, Davis Z, DeFor TE, Schlums H, Zhang B, Brunstein CG, Blazar BR, Wagner J, Diamond DJ, Verneris MR, Bryceson YT, Weisdorf DJ, Miller JS. CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT. Leukemia. 2016;30(2):456-463.
  • Cichocki F, Verneris MR, Cooley S, Bachanova V, Brunstein CG, Blazar BR, Wagner J, Schlums H, Bryceson YT, Weisdorf DJ, Miller JS. The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer. Curr Top Microbiol Immunol. 2016;395:225-243.
  • Schlums H*, Cichocki F*, Tesi B, Theorell J, Beziat V, Holmes TD, Han H, Chiang SC, Foley B, Mattsson K, Larsson S, Schaffer M, Malmberg KJ, Ljunggen HG, Miller JS, Bryceson YT. Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function. Immunity. 2015;42(3):443-456. (* Co-1st authors)
  • Cichocki F, Schlums H, Stache V, Holmes T, Lenvik TR, Chiang SC, Miller JS, Meeths M, Anderson SK, Bryceson YT. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. J Exp Med. 2014;211(6):1079-1091.
  • Cichocki F, Miller JS, Anderson SK, Bryceson YT. Epigenetic regulation of NK cell differentiation and effector functions. Front Immunol. 2013;4:55 (eCollection).
  • Cichocki F, Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz CT, Miller JS. Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol. 2011;187(12):6171-6175.
  • Cichocki F, Miller JS, Anderson SK. Killer immunoglobulin-like receptor transcriptional regulation: a fascinating dance of multiple promoters. J Innate Immun. 2011;3(3):242-248.
  • Cichocki F, Lenvik T, Sharma N, Yun G, Anderson SK, Miller JS. Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cells. J Immunol. 2010;185(4):2009-2012.
  • Cichocki F, Hanson RJ, Lenvik T, Pitt M, McCullar V, Li H, Anderson SK, Miller JS. The transcription factor c-Myc enhances KIR gene transcription through direct binding to an upstream distal promoter element. Blood. 2009;113(14):3245-3253.