Denis R. Clohisy, M.D. Professor Department of Orthopedic Surgery Northwestern University Medical School, M.D. clohi001@umn.edu 612-626-9934 office 612-624-0636 lab

Research Interests:

Cell biology of cancer-induced bone resorption, mechanism of bone cancer pain and bone cancer-targeted gene delivery system

Research is divided into the evaluation of cancer-induced bone pain and the development of new therapies to treat bone cancer. Each area of investigation focuses around the role of the body’s principal bone-resorbing cell, the osteoclast. Activities of the laboratory focus on developing experimental animal models to emulate human diseases, using those models to identify molecular and cellular bases for bone cancer and its sequelae, and using understanding of the mechanistic pathophysiology to develop novel therapies. Therapies recently developed involve external beam radiation, treatment with osteoclast inhibitors, treatment with anti angiogenesis agents, and treatment with cell-based gene delivery systems.

Selected Recent Publications:

• Clohisy DR, Mantyh PW: Bone cancer pain. Cancere 97 (3 Suppl):866-73, 2003. Abstract
• Nagarajan R, Neglia J, Clohisy DR, Yasui Y, Greenberg M, et al: Education, employment, insurance and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Survey. Cancer 97(10), 2554-64, 2003.Abstract
• Clohisy DR: Metastatic bone disease - future directions. Clinical Orthopaedics and Related Research, 415 Suppl, S95-9, 2003. Abstract
• Ramnaraine ML, Pan W, Goblirsch M, Lynch C, Lewis V, Orchard P, Mantyh PW, Clohisy DR: Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Research, 63(20), 6847-54, 2003. Abstract
• Goblirsch M, Mathews W, Lynch C, Alaei P, Gerbi BJ, Mantyh PW, Clohisy DR: Radiation treatment decreases bone cancer pain, osteolysis and tumor size. Radiation Research, 161; 228-234, 2003. Abstract
• Clohisy DR and Mantyn PW: Bone cancer pain. Clin Orthop, 2003 (415 Suppl), S279-88. Abstract
• Nagarajan R, Clohisy DR, Neglia J, et al: Function and quality of life of survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Study. British Journal of Cancer (91), 1858-1865, 2004. Abstract
• Pan W, Mathews W, Donohue JM, Ramnaraine ML, Lynch C, Selski D, Walsh N, Cassady IA, Clohisy DR: Analysis of distinct tartrate-resistant acid phosphatase promoter regions in transgenic mice. In press, Journal of Biological Chemistry, 2004. Abstract
  
  
  Last modified on: January 19, 2005