MICaB Graduate Program
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Craig E. Eckfeldt, M.D., Ph.D.
Department of Medicine
Division of Hematology, Oncology and Transplantation
University of Minnesota, Ph.D., 2005
University of Minnesota, M.D., 2007
Ras signaling, acute myeloid leukemia (AML)
The goal of our research is to investigate the genetics and signaling pathways that drive acute myeloid leukemia (AML) to provide a foundation for the development of novel treatment approaches. A major focus of our research is identifying the critical mediators of RAS signaling that drive AML growth and survival using molecular genetic approaches in the most clinically relevant genetically engineered mouse models, AML cell lines, and primary AML patient samples in vitro and in patient-derived AML xenografts. We are evaluating the role of clinically-relevant signaling pathway inhibitors alone and in combination with chemotherapeutic and immune therapy approaches to maximize the translational potential of our studies. We utilize cutting-edge genomic, proteomic, and flow cytometric approaches to characterize AML treatment response and mechanisms of treatment resistance. Overall, these translational studies will provide novel insights for the development and clinical translation of rationally designed targeted therapies for AML patients.
Selected Recent Publications:
- Zohar Sachs, Raha A. Been, Krista J. DeCoursin, Hanh T. Nguyen, Nurul A. Mohd Hassan, Klara E. Noble-Orcutt, Craig E. Eckfeldt, Emily J. Pomeroy, Ernesto Diaz-Flores, Jennifer L. Geurts, Meichaleen D. Diers, Diane E. Hasz, Kelly J. Morgan, Margaret L. MacMillan, Kevin M. Shannon, David A. Largaespada, and Stephen M. Wiesner. Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency. Haematologica. 2016 (in press).
- Patrick J. Boland, Livia T. Hegerova, Sarah J. Williams, Robert W. McKenna, Veronika Bachanova, and Craig E. Eckfeldt. Successful treatment of two cases of classical Hodgkin Lymphoma-associated hemophagocytic lymphohistiocyosis with R-CEPP. Leukemia & Lymphoma. 2016 (in press).
- Eckfeldt CE, Randall N, Shanley RM, Yohe S, Bejanyan N, Dolan M, Warlick ED, Verneris MR, Brunstein CG, Wagner JE, Weisdorf DJ, Ustun C. 2016. Umbilical cord blood transplantation is a suitable option for consolidation of acute myeloid leukemia with FLT3-ITD. Haematologica. (in press).
- Patterson LJ, Gering M, Eckfeldt CE, Green AR, Verfaillie CM, Ekker SC, Patient R. 2007. The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood. 109(6):2389-98.
- Pickart MA, Klee EW, Nielsen AL, Sivasubbu S, Mendenhall EM, Bill BR, Chen E, Eckfeldt CE, Knowlton M, Robu ME, Larson JD, Deng Y, Schimmenti LA, Ellis LB, Verfaillie CM, Hammerschmidt M, Farber SA, Ekker SC. 2006. Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One. 1:e104.
- Eckfeldt CE, Mendenhall EM, Verfaillie CM. 2005. The molecular repertoire of the 'almighty' stem cell. Nat Rev Mol Cell Biol. 6(9):726-37.
- Eckfeldt CE, Mendenhall EM, Flynn CM, Wang TF, Pickart MA, Grindle SM, Ekker SC, Verfaillie CM. 2005. Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biol. 3(8):e254.
- Leung AY, Mendenhall EM, Kwan TT, Liang R, Eckfeldt C, Chen E, Hammerschmidt M, Grindley S, Ekker SC, Verfaillie CM. 2005. Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos. Dev Biol. 277(1):235-54.
- Hematti P, Hong BK, Ferguson C, Adler R, Hanawa H, Sellers S, Holt IE, Eckfeldt CE, Sharma Y, Schmidt M, von Kalle C, Persons DA, Billings EM, Verfaillie CM, Nienhuis AW, Wolfsberg TG, Dunbar CE, Calmels B. 2004. Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol. 2(12):e423.
- Bertrand FE, Eckfeldt CE, Lysholm AS, LeBien TW. 2000. Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. Leukemia. 14(12):2095-102.
- Bertrand FE, Eckfeldt CE, Fink JR, Lysholm AS, Pribyl JA, Shah N, LeBien TW. 2000. Microenvironmental influences on human B-cell development. Immunol Rev. 175:175-86.