MICaB Graduate Program
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Geoffrey Hart, Ph.D.
Division of Infectious Diseases and International Medicine
Department of Medicine
University of Minnesota, Ph.D.
Human immunology of malaria
There is no approved vaccine for malaria, and there are still many fundamental unanswered questions for malaria immunity. The Hart lab believes many of these unanswered questions lie where innate immunity intersects with the adaptive immune system. Using a basic immunology approach, they collaborate with on-going studies in malaria endemic regions of Africa. Current malaria projects center around understanding the mechanism of antibody mediated immunity and innate regulatory mechanisms (or lack thereof) in pathological immune responses. We use human subject samples primarily for our studies, and we are also developing novel mouse models to better understand in vivo dynamics where needed.
Dr. Hart is a new Primary Investigator in the MICaB program and is excited to train and mentor the next generation of MICaB graduate students. Rotation spots are currently available for the 2017 incoming class. Please apply via email (firstname.lastname@example.org).
- Hart, G.T., Akkaya, M., Chida, A.S., Wei, C., Jenks, S.A., Tipton, C., He, C., Wendel, B.S., Skinner, J., Arora, G., Kayentao, K., Ongoiba, A., Doumbo, O., Traore, B., Narum, D.L., Jiang, N., Crompton, P.D., Sanz, I., and Pierce S.K. 2016 The Regulation of Inherently Autoreactive VH4-34+ Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa. Journal of Immunology 197:3841-9.
- Gordon E.B., Hart G.T.,(co-first) Tran T.M.,Waisberg M., Akkaya M., Kim, A.S., Hamilton, S.E., Pena M., Yazew T., Qi C.F., Lee, C., Lo, Y., Miller L.H., Powell, J.D., Pierce S.K. 2015. Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. PNAS (ePub Oct. 5th,2015).
- Gordon E.B., Hart G.T., (co-first) Tran T.M., Waisberg M., Akkaya M., Skinner J., Zinöcker S., Pena M., Yazew T., Qi C.F., Miller L.H., Pierce S.K. 2015 Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria. mBio 6:e00725.
- Crompton PD, Moebius J, Portugal S, Waisberg M, Hart G, Garver LS, Miller LH, Barillas-Mury C, Pierce SK. 2014. Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annual Reviews in Immunology 32:157-87.
- Hart, G. T., Peery, S. L., Hamilton, S. E., Jameson, S. C. 2012. Cutting Edge: Kruppel-like Factor 2 Is Required for Phenotypic Maintenance but Not Development of B1 B Cells. Journal of Immunology 189: 3293-7.