University of Minnesota
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MICaB Faculty

Kristin Hogquist
Kristin A. Hogquist, Ph.D.

Professor

Department of Laboratory Medicine and Pathology

Washington University (St. Louis), 1991, Ph.D.

612-625-1616 office
612-625-1626 lab
Lab website: http://www.jamequist.umn.edu/

E-mail:hogqu001@umn.edu


Research Interests:

My lab is primarily interested in T cell development in the thymus. We study how selection processes shape the T cell repertoire to achieve a highly effective and self-tolerant adaptive immune system. Current research is focused on these four topics:

Positive selection: This is a crucial stage in T cell development, where MHC restricted progenitors are selected from a random pool. We are systematically studying the gene changes that occur in the T cell progenitor during positive selection and how they support the multiple facets of this event (e.g. survival, migration, allelic exclusion, etc). We are also exploring how cortical epithelial cells support the process of positive selection

Negative selection: One of the ways the immune system copes with self-reactive T cells is to eliminate them from the repertoire. We developed a highly physiologic in vivo mouse model to study the specific antigen presenting cell types involved and the timing and anatomic location of negative selection. We are also exploring why some self- reactive cells undergo apoptosis, but others are selected to become regulatory T cells or NKT cells.

Thymic Emigration: The lab is currently interested in the final stages of maturation that occur prior to migration of the progenitor from the thymus to the periphery. We seek to understand how the functional competence of the cell is eventually switched from apoptosis to proliferation, and the signals, molecular factors, and anatomic structures involved in emigration itself. Recent studies have focused heavily on the transcription factor KLF2.

The Human T cell repertoire: We have a unique collaboration with a clinical virology group to study immune responses in humans that are at high risk for natural infection with a gamma herpesvirus (Epstein Barr Virus or EBV). In addition to documenting the precise changes that occur during the innate and adaptive immune response to this virus, we are exploring how the pre-immune T cell repertoire in such individuals is predisposed to make a pathologic response to this virus (infectious mononucleosis).

 

Selected Recent Publications:

  • Lee YJ, Holzapfel KL, Zhu J, Jameson SC, and KA Hogquist. 2013. Steady state production of IL-4 modulates immunity in different strains and is determined by lineage diversity of iNKT cells.  Nature Immunology 14:1146.
  • Xing Y, Jameson SC, and KA Hogquist. 2013. The thymoproteasome subunit β5T generates pMHC specialized for positive selection.  Proc Natl Acad Sci U S A. 110:6979.
  • Stritesky GL, Xing Y, Erickson JR, Kalekar LA, Mueller DM, Jameson SC, and KA Hogquist. 2013.  Murine thymic selection quantified using a novel method to capture deleted T cells. Proc Natl Acad Sci U S A. 110:4679.
  • Balfour, HH, Odumade, O.A. Schmeling, D.O., Mullan, BD, Ed, JA, Knight, JA, Vezina, HE, Thomas, W and KA Hogquist. 2013.  Virologic, and Immunologic Factors Associated with Acquisition and Severity of Primary Epstein-Barr Virus Infection in University Students. J. Inf. Dis. 207(01):80-8.  
  • REVIEW: Stritesky GL, Jameson SC, Hogquist KA. 2012. Selection of self-reactive T cells in the thymus.  Annu Rev Immunol. 30:95.
  • Odumade, O.A., Knight, J.A., Schmeling, D.O., Masopust D., Balfour, H.H. Jr., and K.A. Hogquist. 2012. Primary Epstein-Barr virus infection does not erode pre-existing CD8 T cell memory in humans.  J. Exp. Med. 209:471.
  • Moran, A.E., Holzapfel K.L. Xing, Y., Cunningham, N.R., Maltzman, J.S., Punt, J., and K.A. Hogquist. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.  J. Exp. Med. 208:1279.
  • REVIEW: Lee, Y.J., Jameson, S.C., and K.A. Hogquist. 2011. Alternative memory in the CD8 lineage. Trends in Immunology 32:50.
  • Weinreich, M.A., Jameson S.C., and K.A. Hogquist. 2011.  Post- selection thymocyte maturation and emigration are independent of  IL-7 and ERK5.  J Immunol. 186:1343.
  • REVIEW: Odumade, O.A., Hogquist, K.A., and H. J. Balfour III. 2011.  Progress and Problems in Understanding and Managing Epstein-Barr Virus Infections.  Clin Microbiol Rev  24:193.
  • Weinreich, M.A., Odumade, O.A., Jameson S.C., and K.A. Hogquist. 2010.  PLZF+ T cells regulate memory-like CD8 T cell development.  Nature Immunology, 11:709.
  • Odumade, O.A., Weinreich M.A., Jameson S.C., and K.A. Hogquist. 2010. Kruppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells.  J. Immunol. 184:6060.
  • Wang L., Jameson, S.C., and K.A. Hogquist. 2009.  Epidermal Langerhans cells are not required for UV induced immunosuppression.  J. Immunol.  183:5548.
  • Weinreich, M.A., Takada K., Skon, C., Reiner, S.L., Jameson, S.C., and K. A. Hogquist. 2009. KLF2 deficiency in T cells results in unrestrained cytokine production and bystander chemokine receptor upregulation.Immunity, 31:122.
  • Bursch, L.S., Rich, B.E., and K.A. Hogquist. 2009. Langerhans cells are not required for the CD8 T cell response to epidermal self antigen. J. Immunol. 182:4657.
  • McCaughtry T.M., Baldwin T.A., Wilken M.S., and K.A. Hogquist. 2008. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J.Exp. Med 205:2575.