Haojie Huang, Ph.D. Assistant Professor Department of Laboratory Medicine and Pathology Nanjing Normal University, 1995, Ph.D. huang253@umn.edu 612-624-3306 office 612-625-9476 lab

Research Interests:

The biochemical and molecular aspects of prostate cancer

Increasing evidence suggests that forkhead transcription factor FOXO1 and transcription co-activator CBP function as tumor suppressors by modulating expression of genes that regulate cell proliferation, apoptosis, oxidative stress or DNA damage repair. Ongoing research in the Huang laboratory is aimed to understand how the potent functions of FOXO1 and CBP are tightly regulated by various post-translational mechanisms, such as phosphorylation, acetylation, and ubiquitination. Moreover, various approaches of biochemistry, molecular biology and genetics are being used in order to systematically assess the impact of dysregulation of these molecules on cell transformation and tumor formation in many organs, particularly in the prostate.

Selected Recent Publications:

• Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. 2006. CDK2-Dependent
  Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage. Science
  314:294-297.

• Huang H, Tindall DJ. 2006. FOXO factors: a matter of life and death. Future
  Oncology 2:83-89.

• Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen J, Tindall
  DJ. 2005. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated
  degradation. Proc Natl Acad Sci USA. 102:1649-1654.

• Huang H, Muddiman DC, Tindall DJ. 2004. Androgens negatively regulate
  forkhead transcription factor FKHR (FOXO1) through a proteolytic
  mechanism in prostate cancer cells. J Biol Chem. 279:13866-13877.

• Huang H, Zegarra-Morro OL, Benson D, Tindall DJ. 2004. Androgens repress
  Bcl-2 expression via activation of the retinoblastoma (RB) protein in
  prostate cancer cells. Oncogene 23: 2161-2176.

• Debes, JD, Schmidt LJ, Huang H, Tindall DJ. 2002. p300 mediates interleukin-6-dependent transactivation of the androgen receptor. Cancer Res. 62: 5632-5636.

• Zegarra-Moro OL, Schmidt LJ, Huang H, Tindall DJ. 2002. Disruption of
  androgen receptor function inhibits proliferation of androgen-refractory
  prostate cancer cells. Cancer Res. 62: 1008-1013.

• Huang H, Cheville JC, Pan Y, Roche PC, Schmidt LJ, Tindall DJ. PTEN
  induces chemosensitivity in PTEN-mutated prostate cancer cells by
  suppression of Bcl-2 expression. J Biol Chem. 2001;276:38830-38836.

Last modified on: December 6, 2006