MICaB Graduate Program
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Marc K. Jenkins, Ph.D.
Distinguished McKnight University Professor
Director, Center for Immunology
Department of Microbiology and Immunology
Northwestern University, 1985, Ph.D.
612-626-2715 - office
612-626-1188 - lab
CD4+ T and B lymphocyte biology
Dr. Jenkins and his colleagues investigate CD4+ T and B cell activation in vivo by directly tracking antigen-specific cells. The goal of this research is a basic understanding of lymphocyte activation that can be used to improve vaccines and prevent autoimmunity.
Selected Recent Publications:
- Tubo, N. J., B. T. Fife, A. J. Pagan, D. I. Kotov, M. F. Goldberg, and M. K. Jenkins. 2016. Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection. Science 351:511.
- Malhotra, D., J. L. Linehan, T. Dileepan, Y. J. Lee, W. E. Purtha, J. V. Lu, R. W. Nelson, B. T. Fife, H. T. Orr, M. S. Anderson, K. A. Hogquist, and M. K. Jenkins. 2016. Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. 17:187.
- Taylor, J. J. , K. A. Pape, H. R. Steach, and M. K. Jenkins. 2015. Apoptosis and antigen affinity limit effector cell differentiation of a single naive B cell. Science 347-784.
- Nelson, R. W. , D. Beisang, N. J. Tubo, T. Dileepan, D. L. Wiesner, K. Nielsen, M. Wuthrich, B.S. Klein, D. I. Kotov, J. A. Spanier, B. T. Fife, J. J. Moon and M. K. Jenkins. 2015. T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity 42:95.
- Tubo, N. J. , A. J. Pagán, J. J. Taylor, R. W. Nelson, J. L. Linehan, J. M. Ertelt, E. S. Huseby, S. S. Way, and M. K. Jenkins. 2013. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 153:785.
- Taylor, J. J., K. A. Pape, and M. K. Jenkins. 2012. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J. Exp. Med. 209:597.
- Pape, K. A., J. J. Taylor, R. W. Mau, P. J. Gearhart, and M. K. Jenkins. 2011. Different B cell populations mediate early and late memory during an endogenous immune response. Science. 331:1203.
- Pepper, M., A. J. Pagán, B. Z. Igyártó, J. J. Taylor, and M. K. Jenkins. 2011. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35:583.
- Pepper, M., J. L. Linehan, A. J. Pagán, T. Zell, T. Dileepan, P. P. Cleary, and M. K. Jenkins. 2010. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat. Immunol. 11:83.
- McLachlan, J. B., D. M. Catron, J. J. Moon, and M. K. Jenkins. 2009. Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity 30:277
- Pape, K. A., D. M. Catron, A. A. Itano, and M. K. Jenkins. 2007. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26:491.
- Moon, J. J., H. H. Chu, M. Pepper, S. J. McSorley, S. C. Jameson, R. M. Kedl and M. K. Jenkins. 2007. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27:203.
- Hataye, J., J. J. Moon, A. Khoruts, C. Reilly, and M.K. Jenkins. 2006. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science 312:114.