MICaB Graduate Program
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Marc K. Jenkins, Ph.D.
Distinguished McKnight University Professor
Department of Microbiology
Northwestern University, 1985, Ph.D.
612-626-2715 - office
612-626-1188 - lab
CD4+ T and B lymphocyte biology
Dr. Jenkins and his colleagues investigate CD4+ T and B cell activation in vivo by directly tracking antigen-specific cells. The goal of this research is a basic understanding of lymphocyte activation that can be used to improve vaccines and prevent autoimmunity.
Selected Recent Publications:
- Taylor, J. J., K. A. Pape, and M. K. Jenkins. 2012. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J. Exp. Med. 209:597.
- Pape, K. A., J. J. Taylor, R. W. Mau, P. J. Gearhart, and M. K. Jenkins. 2011. Different B cell populations mediate early and late memory during an endogenous immune response. Science. 331:1203.
- Pepper, M., A. J. Pagán, B. Z. Igyártó, J. J. Taylor, and M. K. Jenkins. 2011. Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35:583.
- Pepper, M., J. L. Linehan, A. J. Pagán, T. Zell, T. Dileepan, P. P. Cleary, and M. K. Jenkins. 2010. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat. Immunol. 11:83.
- McLachlan, J. B., D. M. Catron, J. J. Moon, and M. K. Jenkins. 2009. Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity 30:277.
- Burchill, M. A., J. Yang, K. B. Vang, J. J. Moon, H. H. Chu, C. W. Lio, A. L. Vegoe, C. S. Hsieh, M. K. Jenkins, and M. A. Farrar. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28:112.
- Pape, K. A., D. M. Catron, A. A. Itano, and M. K. Jenkins. 2007. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26:491.
- Moon, J. J., H. H. Chu, M. Pepper, S. J. McSorley, S. C. Jameson, R. M. Kedl and M. K. Jenkins. 2007. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27:203.
- Hataye, J., J. J. Moon, A. Khoruts, C. Reilly, and M.K. Jenkins. 2006. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science 312:114.
- Catron, D. M., L. K. Rusch, J. Hataye, A. A. Itano, and M. K. Jenkins. 2006. CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central memory cells. J. Exp. Med. 203:1045.
- Catron, D. M., A. A. Itano, K. A. Pape, D. L. Mueller, and M. K. Jenkins. 2004. Visualizing the first 50 hours of the primary immune response to a soluble antigen. Immunity 21:341.
- Reinhardt, R.L., D.C. Bullard, C.T. Weaver, and M.K. Jenkins. 2003. Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J. Exp. Med. 197:751.
- Pape, K. A., V. Kouskoff, D. Nemazee, H. L. Tang, J. G. Cyster, L. E. Tze, K. L. Hippen, T. W. Behrens, and M. K. Jenkins. 2003. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J. Exp. Med.197: 1677.
- Itano, A. A., S. J. McSorley, R. L. Reinhardt, B. D. Ehst, E. Ingulli, A. Y. Rudensky, and M. K. Jenkins. 2003. Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 19:47.
- McSorley, S.J., S. Asch, M. Costalonga, R.L. Reinhardt, and M.K. Jenkins. 2002. Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity 16:365
- Reinhardt, R. L., A. Khoruts, R. Merica, T. Zell, and M. K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101.