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Research Interests:
Stem Cell Biology
Our long-term goal is to understand the pathways that control self-renewal vs differentiation of stem cells and to use this knowledge to design and improve cell therapies. Curren work focuses on mechanistic dissection of regulatory circuits downstream of transcription factors of the Hox, Pax, and bHLH families.
Selected Recent Publications:
- Darabi R, Gelbach K, Bachoo RM, Kamath S, Osawa M, Kamm KE, Kyba M, Perlingeiro RCR. 2008. Functional skeletal muscle regeneration from differentiating embryonic stem cells. Nature Medicine 14:134-143.
- Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K. 2008. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2:497-507.
- Fujita, J, Crane, AM, Souza, MK, Dejosez, M, Kyba, M, Flavell, RA, Thomson, JA, Zwaka, TP. 2008. Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell 2: 595-601.
- Lindsley RC, Gill JG, Murphy TL, Langer EM, Cai M, Mashayekhi M, Wang W, Niwa N, Nerbonne JM, Kyba M, Murphy KM. 2008. Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell 3:55-68.
- Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C. 2008. Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell 3:69-84.
- Ismailoglu I, Yeamans G, Daley GQ, Perlingeiro RCR, Kyba M. 2008. Mesodermal patterning activity of SCL. Exp. Hematol. 36:1593-1603.
- Bosnakovski D, Xu Z, Li W, Thet S, Cleaver O, Perlingeiro RCR, Kyba M. 2008. Prospective isolation of skeletal muscle stem cells with a Pax7 reporter. Stem Cells 26:3194-3204.
- Tang W, Zeve D, Suh J, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM. 2008. White fat progenitor cells reside in the Adipose Vasculature. Science 322:583-536.
- Bosnakovski D, Xu Z, Gang EJ, Galindo CL, Liu M, Simsek T, Garner HR, Agha-Mohammadi S, Tassin A, Frédérique Coppée, Belayew A, Perlingeiro RCR, Kyba M. 2008. An isogenetic myoblast screen identifies DUX4-mediated FSHD-associated molecular pathologies. EMBO J. 27:2766-2779.
- Bosnakovski D, Lamb S, Simsek T, Xu Z, Belayew A, Perlingeiro R, Kyba M. 2008. DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation. Exp. Neurol. (in press).
- Iacovino M, Hernandez C, Xu Z, Bajwa G, Prather M, Kyba M. 2008. A conserved role for Hox paralog group group 4 in regulation of hematopoietic progenitors. Stem Cells Dev. (in press).
Last modified on: March 5, 2009