Carol A. Lange, Ph.D.
Professor
Medicine and Pharmacology
Tickle Family Land Grant Chair in Breast Cancer Research
Co-director, Women's Cancer Program
University of Colorado - Boulder, 1991, Ph.D.
612-626-0621 - office
612-624-1971 - lab
Lab website: http://www.tc.umn.edu/~langelab
E-mail:lange047@umn.edu
Research Interests:
Signal Transduction in Breast Cancer
Dr. Lange's laboratory is focused on the study of cross-talk
between peptide growth factors and steroid hormone receptors
in human breast cancer cells. The ovarian steroid hormones,
estrogen and progesterone, as well as growth factor receptor
tyrosine kinase-initiated signaling pathways are required
for normal breast development, and these pathways also interact
to influence breast tumorigenesis and breast cancer progression.
Ongoing research projects in the laboratory include the study
of the role of protein tyrosine kinases and mitogen acitivated
protein kinase (MAPK) cascades in human breast cancer cell
proliferation and survival, and their contribution to mechanisms
of steroid hormone resistance in human breast cancer. In order
to study problems in breast cancer cell biology, techniques
in signal transduction, endocrinology, protein biochemistry
and molecular biology are employed. Understanding the role
of signaling cross-talk in cell growth control will provide
useful information for the development of better strategies
for the treatment of breast and other hormonally influenced
and/or epithelial cell-derived cancers.
Selected Recent Publications:
- Dressing GE and Lange CA. 2009. Integrated Actions of
Progesterone Receptors and Cell Cycle Machinery Regulate
Breast Cancer Cell Proliferation. Steroids
74(7): 573-576, (invited peer reviewed review).
- Hagan CR, Faivre EJ, and Lange CA. 2009. Scaffolding Actions
of Membrane-Associated Progesterone Receptors. Steroids
74(7): 568-572, (invited peer reviewed review.
- Faivre EJ, Daniel AR, Hillard CJ, Lange CA. 2008. Progesterone
Receptor Rapid Signaling Mediates Ser345 Phosphorylation
and Tethering to Sp1 Transcription Factors. Mol
Endo. 22(4): 823-837.
- Lange CA. 2007. Editorial:Membrane and Nuclear Steroid
Hormone Receptors: two integrated arms of the same signaling
pathway? Steroids.
72(2): 105-106.
- Daniel AR, Faivre EJ, and Lange CA. 2007. Phosphorylation-Dependent
Antagonism of Sumoylation De-represses Progesterone Receptor
Action in Breast Cancer Cells. Mol
Endo, 21 (12); 2890-2906.
- Hanson Ostrander J, Daniel AR, Lofgren K, Kleer CG, and
Lange CA. 2007. Breast Tumor Kinase (Brk/PTK6) Regulates
Heregulin-Induced Activation of ERK5 and p38 MAP Kinases
in Breast Cancer Cells. Cancer
Research, 67(9); 4199-4209.
- Faivre E and Lange CA. 2007. Progesterone Receptors Upregulate
Wnt-1 to Induce EGFR Transactivation and c-Src-depedenent
Sustained Activation of ERK1/2 Mitogen-Activated Protein
Kinase in Breast Cancer Cells. Mol.
Cell. Biol. 27(2); 466-480.
- Daniel AR, Qiu M, Faivre EJ, Ostrander JH, Skildum A,
Lange CA. 2007. Linkage of progestin and epidermal growth
factor signaling: phosphorylation of progesterone receptors
mediates transcriptional hypersensitivity and increased
ligand-independent breast cancer cell growth. Steroids.
Feb;72(2):188-201.
- Lange CA, Gioeli D, Hammes SR, Marker PC. 2007. Integration
of Rapid Signaling Events with Steroid Hormone Receptor
Action in Breast and Prostate Cancer.
Annu
Rev Physiol. 69:171-99.
- Faivre E, Skildum A, Pierson-Mullany L, Lange CA. 2005.
Integration of progesterone receptor mediated rapid signaling
and nuclear actions in breast cancer cell models: role of
mitogen-activated protein kinases and cell cycle regulators. Steroids.
70(5-7):418-26.
- Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons
D, Lange CA. 2005. Regulated association of protein
kinase B/Akt with breast tumor kinase. J
Biol Chem. 280(3):1982-91.
- Pierson-Mullany LK, Lange CA. 2004. Phosphorylation of
progesterone receptor serine 400 mediates ligand-independent
transcriptional activity in response to activation of cyclin-dependent
protein kinase 2. Mol
Cell Biol. 24(24):10542-57.
- Lange CA. 2004. Making Sense of Cross-Talk Between Steroid
Hormone Receptors and Intracellular Signaling Pathways:
Who Will Have the Last Word? Mol
Endo. 18(2):269-78.
- Pierson-Mullany, L, Skildum, A, Faivre, E, and Lange,
CA. 2003. Cross-talk Between Growth Factor and Steroid Receptor
Signaling Pathways: Implications for Breast Cancer Cell
Growth. Breast
Cancer, 18:21-31.
- Qiu, M and Lange, CA. 2003. MAP Kinases Couple Multiple
Functions of Human Progesterone Receptors: Degradation,
Transcriptional Synergy, and Nuclear Localization. J. Steroid
Receptor Biochem. Mol.
Biol. 85: 147-157.
- Qiu, M, Olsen, A, Faivre, E, Horwitz, KB, and Lange, CA.
2003. Mitogen Activated Protein Kinase Regulates Nuclear
Association of Human Progesterone Receptors. Mol.
Endo. 17: 628-642.
- Shen, T, Horwitz, KB, and Lange, CA. 2001. Transcriptional
Hyper-Activity of Human Progesterone Receptors is Coupled
to Their Ligand-Dependent Down-Regulation by Mitogen-Activated
Protein Kinase-Dependent Phosphorylation of Serine 294. Mol.
Cell. Biol. 21: 6122-6131.
Last modified on: July 13, 2010