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Carol A. Lange, Ph.D.
Associate Professor
Department of Medicine
University of Colorado - Boulder, 1991, Ph.D.
lange047@tc.umn.edu
612-626-0621 - office
612-624-1971 - lab
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Research Interests:
Signal Transduction in Breast Cancer
Dr. Lange's laboratory is focused on the study of cross-talk
between peptide growth factors and steroid hormone receptors
in human breast cancer cells. The ovarian steroid hormones,
estrogen and progesterone, as well as growth factor receptor
tyrosine kinase-initiated signaling pathways are required
for normal breast development, and these pathways also interact
to influence breast tumorigenesis and breast cancer progression.
Ongoing research projects in the laboratory include the study
of the role of protein tyrosine kinases and mitogen acitivated
protein kinase (MAPK) cascades in human breast cancer cell
proliferation and survival, and their contribution to mechanisms
of steroid hormone resistance in human breast cancer. In order
to study problems in breast cancer cell biology, techniques
in signal transduction, endocrinology, protein biochemistry
and molecular biology are employed. Understanding the role
of signaling cross-talk in cell growth control will provide
useful information for the development of better strategies
for the treatment of breast and other hormonally influenced
and/or epithelial cell-derived cancers.
Selected Recent Publications:
- Lange CA, Gioeli D, Hammes SR, Marker PC. 2006. Integration of Rapid Signaling Events with Steroid Hormone Receptor Action in Breast and Prostate Cancer.
Annu Rev Physiol. 2006 Oct 12; [Epub ahead of print]
- Faivre E, Skildum A, Pierson-Mullany L, Lange CA. 2005. Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators. Steroids. 70(5-7):418-26.
- Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA. 2005. Regulated association of protein kinase B/Akt with breast tumor kinase. J Biol Chem. 280(3):1982-91.
- Pierson-Mullany LK, Lange CA. 2004. Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2. Mol Cell Biol. 24(24):10542-57.
- Lange CA. 2004. Making Sense of Cross-Talk Between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word? Mol Endo. 18(2):269-78.
- Pierson-Mullany, L, Skildum, A, Faivre, E, and Lange, CA. 2003. Cross-talk Between Growth Factor and Steroid Receptor Signaling Pathways: Implications for Breast Cancer Cell Growth. Breast Cancer, 18:21-31.
- Qiu, M and Lange, CA. 2003. MAP Kinases Couple Multiple Functions of Human Progesterone Receptors: Degradation, Transcriptional Synergy, and Nuclear Localization. J. Steroid Receptor Biochem. Mol. Biol. 85: 147-157.
- Qiu, M, Olsen, A, Faivre, E, Horwitz, KB, and Lange, CA. 2003. Mitogen Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors. Mol. Endo. 17: 628-642.
- Shen, T, Horwitz, KB, and Lange, CA. 2001. Transcriptional Hyper-Activity of Human Progesterone Receptors is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294. Mol. Cell. Biol. 21: 6122-6131.
- Lange, C., T Shen, and KB Horwitz. 2000. Phosphorylation of human progesterone receptors at serine 295 by mitogen activated protein kinase signals their degradation by the 26S proteasome. Proc. Natl. Acad. Sci. USA 97:1032-1037.
- Lange, C.A., J.K. Richer, and K.B. Horwitz. 1999. Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals. Mol. Endo. 13:829-836.
- Lange, CA, JK Richer, T Shen, and KB Horwitz. 1998. Convergence
of progesterone and epidermal growth factor signaling in
breast cancer. Potentiation of mitogen-activated protein
kinase pathways. J.
Biol. Chem 273:31308-31316.
Last modified on: October 24, 2006
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