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MICaB Faculty

mcivor
R. Scott McIvor, Ph.D.

Professor

Department of Genetics, Cell Biology and Development

University of Minnesota, 1982, Ph.D.

612-626-1497 office
612-626-1435 lab

E-mail:mcivo001@umn.edu


Research Interests:

Gene therapy

The general research interest of Dr. McIvor's laboratory is gene therapy for genetic diseases and cancer. Specific research activities include: (i) Use of recombinant retroviral and lentiviral vectors for gene transfer into hematopoietic stem cells in the treatment of cancer and inherited disorders such as immunodeficiency diseases and lysosomal storage diseases; (ii) Introduction of drug-resistance genes into normal hematopoietic cells to protect against the toxic side effects of cancer chemotherapy; (iii) Use of adeno-associated virus for treatment of storage diseases and as a vector for gene transfer into the central nervous system in the treatment of neurological disorders; (iv) Adaptation of a novel vertebrate transposon ("Sleeping Beauty") to viral and non-viral delivery systems for gene therapy.

Selected Recent Publications:

  • Aronovich, E.L., B.C. Hall, J.B. Bell, R.S. McIvor, and P.B. Hackett.  Quantitative Analysis of α-L-Iduronidase Expression in Immunocompetent Mice Treated with the Sleeping Beauty Transposon System.  PLoS One, in press.
  • Suksanpaisan, L.,  L. Pham, S. McIvor, S.J. Russell and K-W Peng. Oral contrast enhances the resolution of in-life NIS reporter gene imaging.  Cancer Gene Therapy, in press.
  • Janson C.G., L.G. Romanova, P. Leone P, Z. Nan, L. Belur, R.S. McIvor, W. Low.  2013.  Comparison of Endovascular and Intraventricular Gene Therapy with AAV5-IDUA for Hurler's Disease. Neurosurgery, in press.
  • Gori, J.L.,  B.C. Beard, N.P. Williams, C. Ironside, D. Swanson, R.S. McIvor, and H.P. Kiem.  2013.  In vivo protection of activated Tyr22-dihydrofolate reductase gene-modified canine T lymphocytes from methotrexate. J Gene Med. 15: 233-241.
  • Adil, M., L. Belur, R.M. Levine, A.W. Tisdale, R.S. McIvor, and E. Kokkoli.  PR_b functionalized stealth liposomes for targeted delivery to metastatic colon cancer. Biomaterials Science 1: 393-401.
  • Schuster, D.J., J.A. Dykstra, M.S. Riedl, K.F. Kitto, C.N. Honda, R.S. McIvor, C.A. Fairbanks, and L. Vulchanova. 2013. Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression.  Neurogastroenterol Motil. 25; e89–e100.
  • Filareto, A., S. Parker, R. Darabi, L. Borges, T. Schaaf, T. Mayerhofer, J.S. Chamberlain, J.M. Ervasti, R.S. McIvor, M. Kyba and R.C.R. Perlingeiro.  2013.  An ex vivo gene therapy approach to treat muscular dystrophy using iPS cells.  Nature Communications 4: 1549.
  • Wolf, D.A., A.W. Lenander, Z. Nan, E.A. Braunlin, K.M. Podetz-Pedersen, C.B. Whitley,P. Gupta, W.C. Low, and R.S. McIvor. 2012.  Increased longevity and metabolic correction following syngeneic bone marrow transplantation in a murine model of mucopolysaccharidosis type I.  Bone Marrow Transplantation 47: 1235-1240.
  • Wolf, D.A., L.R. Hanson, Z. Nan, W.C. Low, W.H. Frey II, and R.S. McIvor.  2012.  Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal Administration.  Molecular Genetics and Metabolism 106: 131-134.
  • Hyland, K.A., E.R. Olson, K.J. Clark,  E.L. Aronovich, P.B. Hackett, B.R. Blazar,  J. Tolar, and R.S. McIvor.   2011.  Sleeping Beauty-mediated correction of Fanconi anemia type C. Journal of Gene Medicine 13: 462-469.
  • Wilber, A, F.U. Montoya, L. Hammer, B.S. Moriarity, A.M. Geurts, D.A. Largaespada, C.M. Verfaillie, R.S. McIvor, and U. Lakshmipathy. 2011. Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.  Stem Cells International, 2011:717069.
  • Multhaup, M.M, S. Gurram, K.M. Podetz-Pedersen, A.D. Karlen, D.L. Swanson, N.V. Somia, P.B. Hackett, M.J. Cowan, and R.S. McIvor.  2011.  Characterization of the human Artemis promoter by heterologous gene expression in vitro and in vivo.  DNA and Cell Biology 30: 751-761.
  • Wolf, D.A., A.W. Lenander, Z. Nan, L.R. Belur, C.B. Whitley, P. Gupta, W.C. Low, and R.S. McIvor.  2011.  Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I. Neurobiol. Disease 43: 123-133.
  • Belur L,R., K.M.Podetz-Pedersen, B.S. Sorenson, A.H. Hsu, J.B. Parker, C.S. Carlson, D.A. Saltzman, S. Ramakrishnan, and R.S. McIvor.  2011.  Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System. Mol Cancer 10 (1) 14.