Stephen J. McSorley, Ph.D. Associate Professor Department of Medicine Glasgow University, 1995, Ph.D. mcsor002@umn.edu 612-626-9905 office 612-626-9959 lab

Research Interests:

Immunity to Salmonella

Salmonella typhi causes typhoid fever, a common infection in a many developing nations. The World Health Organization estimates that there are around 17 million cases of typhoid fever per year and of these approximately 600,000 are fatal. Current typhoid vaccines are only moderately effective or unsafe for use by the very young or elderly. Research in our laboratory focuses on understanding the activation of innate and adaptive immune responses to Salmonella with a view to development of novel typhoid vaccines. The activation of mucosal T cells in response to enteric pathogens bears many similarities to the activation of mucosal T cells during Inflammatory Bowel Disease (IBD). Our laboratory is also actively developing a novel model of antigen-specific colitis and attempting to identify how and where T cells responsive to normal enteric flora are activated in vivo.

Selected Recent Publications:

• Salazar-Gonzalez, R.M., J.H. Niess, D.J. Zammit, R. Ravindran, A. Srinivasan,
  J.R. Maxwell, T. Stoklasek, R. Yadav, I.R. Williams, X. Gu, B.A. McCormick,
  M.A. Pazos, A.T. Vella, L. Lefrancois, H-C. Reinecker, and S.J. McSorley.
  2006. CCR6-mediated dendritic cell activation of pathogen-specific T cells
  in Peyer's patches. Immunity 24:623-632.

• Ravindran, R., J. Foley, T. Stoklasek, L.H. Glimcher, and S.J. McSorley.
  2005. Expression of T-bet by CD4 T cells is essential for resistance to
  Salmonella infection. J. Immunol. 174:4603.

• Srinivasan, A., J. Foley, and S.J. McSorley. 2004. Massive clonal
  expansion of antigen-specific CD4 T cells during vaccination with live
  attenuated Salmonella induces clonal competition. J. Immunol. 172:6884.

• Srinivasan, A., J. Foley, R. Ravindran, and S.J. McSorley. 2004. Low dose
  Salmonella infection evades activation of flagellin-specific CD4 T cells.
  J. Immunol. 173:4091.

• Srinivasan, A., and S.J. McSorley. 2004. Visualizing the immune response
  to pathogens. Curr. Opin. Immunol. 16:494.
  
  Last modified on: August 10, 2006