University of Minnesota
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MICaB Faculty

Zohar Sachs, M.D., Ph.D.

Assistant Professor

Department of Medicine

Tufts University, M.D., Ph.D.

612-626-7055 office

Research Interests:

Acute myeloid leukemia stem calls

My lab’s goal is to identify molecular mechanisms of leukemia stem cell self-renewal in primary murine and human acute myeloid leukemia (AML). Self-renewal is a feature of leukemia stem cells that allow them to recapitulate leukemia and cause relapse. Since AML cells are highly heterogenous, we specialize in the application of single-cell, high throughput technologies (including mass cytometry/CyTOF and single-cell RNA sequencing) to address these research questions.

My earlier work demonstrated that the activated NRAS oncogene mediates self-renewal in AML and that individual leukemia cells vary significantly in their functional status and ability to self-renew (Sachs et al. Blood 2014). Recently, we defined the gene expression profile of AML self-renewal at the single-cell level and used this data to identify a functionally unique subset of leukemia cells with leukemia-repopulating potential. We are using these approaches to identify effective therapeutic targets for this deadly disease.

Selected Publications:

  • Maus R, Jakub JW, Nevala W, Christensen T, Noble-Orcutt K, Sachs Z, Hieken T,  Markovic SN. 2017. “Human melanoma-derived extracellular vesicles regulate dendritic cell maturation.” Frontiers in Immunology March 29;8:358.
  • Baughn LB*, Sachs Z*, Noble-Orcutt KE, Mitra A, Van Ness BG, and Linden MA. 2017.“Phenotypic and functional characterization of a bortezomib resistant multiple myeloma cell line by flow and mass cytometry.” Leukemia and Lymphoma 58(8):1931-1940. *co-first authors
  • Csizmar CM, Kim DH, Sachs, Z. 2016. .“The Role of the Proteasome in AML.” Blood Cancer Journal. Dec 2;6(12)e503.
  • Sachs Z, Been RA, DeCoursin KJ, Nguyen HT, Mohd Hassan NA, Noble-Orcutt KE, Eckfeldt CE, Pomeroy EJ, Diaz-Flores E, Geurts JL, Diers MD, Hasz DE, Morgan KJ, MacMillan ML, Shannon KM, Largaespada DA, Wiesner SM. 2016. “Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency.” Haematologica. Oct;101(10):1190-1199.
  • Yun YS, Kim KH, Tschida B, Sachs Z, Noble-Orcutt KE, Moriarity B, Ai T, Ding R, Williams J, Chen L, Largaespada DA, Kim D. 2016. “mTORC1 Regulates Immunoproteasome Assembly for Protein Stress Response and Cell Survival.” Molecular Cell. Feb 18;61(4):625-39.
  • Moench L, Sachs Z, Aasen G, Dolan M, Dayton V, Courville EL. 2016.“Double- and Triple-Hit Lymphomas Can Present with Immature Features, including TdT Expression, and Create Diagnostic Challenges.” Leukemia and Lymphoma. Feb 18:1-10.
  • Trottier BJ, Sachs Z, DeFor TE, Shune L, Dolan M, Weisdorf DJ, Ustun C, Warlick ED. 2016. “Novel Disease Burden Assessment Predicts Allogeneic Transplantation Outcomes in Myelodysplastic Syndrome.” Bone Marrow Transplant. Feb;51(2):199-204.
  • Courville EL, Sachs Z, Linden MA. “Plasma Cell Neoplasms: A morphologic, cytogenetic, and Immunophenotypic approach.” Book chapter; Linden MA, McKenna RW, Editors. New York, NY: Springer; 2015. Standardized synoptic reports for plasma cell neoplasms: integration of laboratory and clinical data.
  • Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. 2015. “Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.”  Bioorg Med Chem. Aug 1;23(15):4737-45.
  • Ustun C, Trottier BJ, Sachs Z, DeFor TE, Shune L, Courville E, Holtan SG, Dolan M, Weisdorf DJ, Warlick ED. 2015. “Monosomal karyotype at the time of diagnosis or transplantation predicts outcomes of Allogeneic Hematopoietic Cell Transplantation in Myelodysplastic Syndrome.” Biol Blood Marrow Transplant. Jan 22. 21(5):866-72.
  • Sachs Z, LaRue RS, Nguyen HT, Sachs K, Noble KE, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA. 2014. NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.” Blood. Nov 20;124(22):3274-83.