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Patrick Schlievert, Ph.D.
Professor
Department of Microbiology
University of Iowa, 1976, Ph.D.
schli001@umn.edu
612-624-1484 - office
612-624-9471 - lab
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Research Interests:
Molecular pathogenesis and immunology; streptococci and staphylococci
Research in my laboratory studies both exotoxins made by
Staphylococcus aureus and group A streptococci and
the pathogenesis of enterococcal endocarditis. Specifically,
the exotoxins investigated are pyrogenic toxin superantigens.
Included in this larger family are toxic-shock syndrome toxin-1
(TSST-1), a cause of TSS; staphylococcal enterotoxins, causes
of food poisoning and some TSS; and streptococcal pyrogenic
exotoxins, causes of scarlet fever and a toxic shock syndrome-like
illness. Specific areas of ongoing research include: 1) elucidation
of the mechanism of T cell alteration by the toxins and correlation
with illnesses such as TSS, scarlet fever, autoimmunity, and
lymphoproliferative diseases; 2) elucidation of the mechanism
of enhanced susceptibility to lethal shock and heart damage;
3) molecular genetic analysis of mechanisms controlling expression
of the toxins; and 4) elucidation of the mechanism of toxicity
for endothelial cells. Finally, studies are underway to characterize
the bacterial cell surface factors required to induce endocarditis.
Selected Recent Publications:
- Peterson, M.L., K. Ault, M.J. Kremer, A.J. Klingelhutz, C.C. Davis, C.A. Squier, P.M. Schlievert. (2005) The Innate Immune System is Activated by Stimulation of Vaginal Epithelial Cells with Staphylococcus aureus a Toxic Shock Syndrome Toxin 1. Infect Immun, 73(4):2164-2174.
- Kravitz, G.R., D.J. Dries, M.L. Peterson, P.M. Schlievert. (2005) Purpura Fulminans Due to Staphylococcus aureus. Clin Infect Dis. 40(7):941-7.
- Pragman, A.A., J.M. Yarwood, T.J. Tripp, P.M. Schlievert. (2004) Characterization of Virulence Factor Regulation by SrrAB, a Two-Component System in Staphylococcus aureus. J Bacteriol. 186(8):2430-8.
- Patrick M. Schlievert, Olivia N. Chuang, Marnie L. Peterson, Suzanne M. Grindle, Laura C. Case, Gary M. Dunny. Reduction of Enterococcus faecalis Endocarditis with IgG Fab Fragments that Interfere with Aggregation Substance-Mediated Immune Response Suppression. In Review. Link to SUPPLEMENTARY DATA
Microarray studies
Purpura Fulminans
Staphylococcus aureus Purpura
Fulminans
Last updated: October 5, 2005
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