Janet L. Schottel, Ph.D. Professor Department of Biochemistry, Molecular Biology and Biophysics Washington University, 1977, Ph.D. schot002@tc.umn.edu 612-624-6275 office 612-624-1737 lab

Research Interests:

mRNA Stability: Plant-Pathogen Interactions; Gene Expression

One of my primary research interests focuses on the regulation of gene expression in cells in response to stress such as nutrient deprivation, culture density, osmotic stress, heat shock, and mechanical stress. Our approaches include studying the regulation of transcription, mRNA degradation and protein synthesis in cells grown under a variety of culture conditions. In addition, we are studying the physiology of cells immobilized in latex and the development of these biofilms as biocatalysts and biosensors. In another research program, my laboratory is studying the interaction between pathogenic streptomycetes and their host plants. Streptomyces scabies causes scab disease on a variety of underground vegetables. In this system, we are characterizing phytotoxins produced by the pathogen that are involved in eliciting lesion formation on the plant, elucidating the biosynthetic pathway of the phytotoxin, and studying the mechanism of biological control of this disease.

Selected Recent Publications:

• Ryan, A.D., L.L. Kinkel, and J.L. Schottel. 2003. Effects of pathogen isolate, potato cultivar, and antagonist strain on potato scab severity and biological control. Biocontrol Sci Tech., in press.
• Schottel, J.L., K. Shimizu, and L.L. Kinkel. 2001. Relationships of in vitro pathogen inhibition and soil colonization to potato scab biocontrol by antagonistic Streptomyces spp. Biol. Control. 20:102-112.
• Neeno-Eckwall, E.C., L.L. Kinkel, and J.L. Schottel. 2001. Competition and antibiosis in the biological control of potato scab. Can. J. Microbiol. 47:332-340.
• Lyngberg, O.K., D.J. Stemke, J.L. Schottel, and M.C. Flickinger. 1999. A single-use luciferase-based mercury biosensor using Escherichia coli HB101 immobilized in a latex copolymer film. J. Ind. Microbiol. Biotechnol. 23:668-676.
• Thiagarajan, V.S., Z. Huang, L.E. Scriven, J.L. Schottel, and M.C. Flickinger. 1999. Microstructure of a biocatalytic latex coating containing viable Escherichia coli cells. J. Coll. Inter. Sci. 215:244-257.
• Lyngberg, O.K., V. Thiagarajan, D.J. Stemke, J.L. Schottel, L.E. Scriven and M.C. Flickinger. 1999. A patch coating method for preparing biocatalytic films of Escherichia coli. Biotechnol. Bioeng. 62:44-55.
• Neeno-Eckwall, E.C. and J.L. Schottel. 1999. Occurrence of antibiotic resistance in the biological control of potato scab disease. Biol. Control 16:199-208.
• Kinkel, L.L., Bowers, J.H., Shimizu, K., Neeno-Eckwall, E.C. and Schottel, J.L. 1998. Quantitative Relationships Among Thaxtomin A Production, Potato Scab Severity, and Fatty Acid Composition in Streptomyces. Can. J. Microbiol. 44:768-776.
• Kuzj, A.E.S., P.S. Medberry, and J.L. Schottel. 1998. Stationary phase, amino acid limitation and recovery from stationary phase modulate the stability and translation of chloramphenicol acetyltransferase mRNA and total mRNA in Escherichia coli. Microbiol. 144:739-750.
• Eckwall, E.C. and J.L. Schottel. 1997. Isolation and characterization of an antibiotic produced by the scab disease suppressive S. diastochromogenes strain PonSSII. J. Indus. Microbiol. Biotechnol. 19:220-225.
• Becker, D., L.L. Kinkel, and J.L. Schottel. 1997. Evidence for interspecies communication and its potential role in pathogen suppression in a naturally occurring disease suppressive soil. Can. J. Microbiol. 43:985-990.
• Search PubMed for Schottel

Last modified on: December 23, 2003