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Janet L. Schottel, Ph.D.
Professor
Department of Biochemistry, Molecular Biology and Biophysics
Washington University, 1977, Ph.D.
schot002@tc.umn.edu
612-624-6275 office
612-624-1737 lab
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Research Interests:
mRNA Stability: Plant-Pathogen Interactions; Gene Expression
One of my primary research interests focuses on the regulation of gene
expression in cells in response to stress such as nutrient deprivation,
culture density, osmotic stress, heat shock, and mechanical stress. Our
approaches include studying the regulation of transcription, mRNA degradation
and protein synthesis in cells grown under a variety of culture conditions.
In addition, we are studying the physiology of cells immobilized in latex
and the development of these biofilms as biocatalysts and biosensors.
In another research program, my laboratory is studying the interaction
between pathogenic streptomycetes and their host plants. Streptomyces
scabies causes scab disease on a variety of underground vegetables.
In this system, we are characterizing phytotoxins produced by the pathogen
that are involved in eliciting lesion formation on the plant, elucidating
the biosynthetic pathway of the phytotoxin, and studying the mechanism
of biological control of this disease.
Selected Recent Publications:
- Ryan, A.D., L.L. Kinkel, and J.L. Schottel. 2003. Effects
of pathogen isolate, potato cultivar, and antagonist strain
on potato scab severity and biological control. Biocontrol
Sci Tech., in press.
- Schottel, J.L., K. Shimizu, and L.L. Kinkel. 2001. Relationships
of in vitro pathogen inhibition and soil colonization
to potato scab biocontrol by antagonistic Streptomyces
spp. Biol. Control. 20:102-112.
- Neeno-Eckwall, E.C., L.L. Kinkel, and J.L. Schottel. 2001.
Competition and antibiosis in the biological control of
potato scab.
Can. J. Microbiol. 47:332-340.
- Lyngberg, O.K., D.J. Stemke, J.L. Schottel, and M.C. Flickinger.
1999. A single-use luciferase-based mercury biosensor using
Escherichia coli HB101 immobilized in a latex copolymer
film. J.
Ind. Microbiol. Biotechnol. 23:668-676.
- Thiagarajan, V.S., Z. Huang, L.E. Scriven, J.L. Schottel,
and M.C. Flickinger. 1999. Microstructure of a biocatalytic
latex coating containing viable Escherichia coli
cells. J.
Coll. Inter. Sci. 215:244-257.
- Lyngberg, O.K., V. Thiagarajan, D.J. Stemke, J.L. Schottel,
L.E. Scriven and M.C. Flickinger. 1999. A patch coating
method for preparing biocatalytic films of Escherichia
coli. Biotechnol.
Bioeng. 62:44-55.
- Neeno-Eckwall, E.C. and J.L. Schottel. 1999. Occurrence
of antibiotic resistance in the biological control of potato
scab disease. Biol. Control 16:199-208.
- Kinkel, L.L., Bowers, J.H., Shimizu, K., Neeno-Eckwall,
E.C. and Schottel, J.L. 1998. Quantitative Relationships
Among Thaxtomin A Production, Potato Scab Severity, and
Fatty Acid Composition in Streptomyces. Can. J. Microbiol.
44:768-776.
- Kuzj, A.E.S., P.S. Medberry, and J.L. Schottel. 1998.
Stationary phase, amino acid limitation and recovery from
stationary phase modulate the stability and translation
of chloramphenicol acetyltransferase mRNA and total mRNA
in Escherichia coli. Microbiol.
144:739-750.
- Eckwall, E.C. and J.L. Schottel. 1997. Isolation and
characterization of an antibiotic produced by the scab disease
suppressive S. diastochromogenes strain PonSSII.
J. Indus. Microbiol. Biotechnol. 19:220-225.
- Becker, D., L.L. Kinkel, and J.L. Schottel. 1997. Evidence
for interspecies communication and its potential role in
pathogen suppression in a naturally occurring disease suppressive
soil. Can. J. Microbiol. 43:985-990.
- Search PubMed
for Schottel
Last modified on: December 23, 2003
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