University of Minnesota
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MICaB Faculty

Subbaya Subramanian
Subbaya Subramanian, Ph.D.

Associate Professor

Department of Surgery

Center for Cellular and Molecular Biology, India, 2003, Ph.D.
(Affiliated to Jawaharlal Nehru University)

612-626-4330 office
612-626-2735 lab

Research Interests:

microRNA mediated gene regulation in cancer

Our laboratory is basically interested in understanding the microRNA (miRNA) mediated gene regulatory networks in sarcoma and other cancer types. We explore miRNA-mRNA associations that have potential role in tumor onset, progression, and aggressiveness through miRNA and mRNA profiling as well as functional characterization of candidate miRNAs using in vitro and in vivo approaches. This will aid in the identification and development of novel miRNA-based biomarkers and targets for therapy. Our laboratory also is interested in engineering miRNA dysregulation in vivo and developing assays for screening small molecule inhibitors that can potentially modulate miRNA expression. The specific areas of research includes

  1. Understanding the role of miRNAs in malignant transformation process.
  2. Characterization of miRNA regulatory networks using comparative oncology of human and canine osteosarcoma.
  3. Molecular mechanisms of microRNA expression and regulations.

Selected Recent Publications:

  • Sarver A, Phalak R, Thayanithy V, Subramanian S. S-MED: Sarcoma microRNA Expression Database. Lab Invest 2010 (in press)
  • Subramanian S, Thayanithy V, West RB et al. Genome-wide transcriptome analyses reveals p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumors. J Pathol 2010 220: 58-70
  • Subramanian S and Steer CJ, MicroRNAs as gatekeepers of apoptosis. J Cell Physiol 2010 (in press)
  • Wang L, Tang H, Thayanithy T, Subramanian S, et al. Gene networks and microRNAs implicated in aggressive prostate cancer. Cancer Res 2009 69:9490-9497
  • Lee CH, Subramanian S, Beck AH, et al. MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation carrying high-grade serous carcinomas of ovary. PLoS One 2009 4(10):e7314
  • Sarver AL, French A, Borralho PM et al. Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer 2009 9:401
  • Wang L, Oberg AL, Asmann et al. Genome-wide transcriptional profiling reveals microRNA-correlated genes and pathways in human lymphoblastoid cell lines. PLoS One 2009 4 (6): e5878
  • Subramanian S, Lui WO, Lee CH, et al. MicroRNA expression signature of human soft tissue tumors. Oncogene 2008 27; 2015-2026
  • Lubieniecka JM, de Bruijn D, Su L,van Dijk A, Subramanian S, et al. Histone deacetylase inhibitors reverse SS18-SSX mediated polycomb silencing of the tumor suppressor EGR1 in synovial sarcoma. Cancer Res 2008 68: 4303-4310
  • Lee C, Espinosa I, Vrijaldenhoven S, Subramanian S, et al. Prognostic significance of macrophage marker in leiomyosarcomas. Clin Caner Res 2008 14; 1423-1430
  • West RB, Rubin BP, Miller M, Subramanian S, et al. CSF1-COL6A3 gene fusion is present in a minority of tumor cells in tenosynovial giant cell tumor and pigment villonodular synovitis. Proc Natl Acad Sci USA 2006 103:690-695
  • Subramanian S, West RB, Marinelli RJ, Nielsen et al. Gene expression profile of extraskeletal myxoid chondrosarcoma. J Pathol 2005 206:433-444
  • West RB, Nuyten DSA, Subramanian S, et al. Stromal Expression Signatures Predict Outcome in Breast Carcinoma. PLoS Biol 2005 3:3187Subramanian S, West RB, Corless CL, Ou W, et al. Gastrointestinal Stromal Tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene 2004 23: 7780-7790
  • Subramanian S, Mishra RK and Singh L Genome-wide analysis of microsatellite repeats in human: Abundance and their density in specific genomic regions Genome Biol. 2004 4:R13
  • Subramanian S, Mishra RK and Singh L. Genome-wide analysis of Bkm sequences (GATA repeats): Predominant association with sex chromosomes and potential role in higher order chromatin organization and function. Bioinformatics 2003 19: 681-685
  • Subramanian S, Madugula VM, George R, et al. Triplet repeats analysis in human genome: Abundance, distribution and association with genes and other genomic regions. Bioinformatics 2003 19: 549-552
  • Subramanian S, Madugula VM, George R et al. SSRD: A simple sequence repeat database for human genome. Comparative and Functional Genomic 2003 4: 342-34
    Research Track: Cancer Biology