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SingSing Way, M.D., Ph.D.
Assistant Professor
Departments of Pediatrics and Microbiology
Albert Einstein College of Medicine, 1999, M.D.,
Ph.D.
singsing@umn.edu
office - 612-626-2526
lab - 612-624-8875
fax - 612-626-9924
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Research Interests:
T cell response to infection
Our laboratory examines the immune response to infection
with the long-term goal of more rational vaccine design. Since
available vaccines can efficiently prime antibody-mediated
immunity, we primarily focus on examining the biology of how
pathogen-specific CD4 and CD8 T cells are primed, activated,
and differentiate from effector into memory cells. For these
studies, we use Listeria monocytogenes infection
in the mouse as an experimental model, and combine making
modifications in either the pathogen and/or the host to examine
the biological parameters necessary for generating protective
T cell immnity. Current ongoing work focuses on (1) defining
the innate cytokine mileau that results in activation and
differentiation of antigen-specific CD4 and CD8 T cells, (2)
testing the ability of recombinant Listeria for
use as vaccine vectors after expression heterologous antigens
from other pathogens into attenuated Listeria strains,
and (3) exploring potential differences priming T cell mediated
immunity in neonates compared with adults.
Pediatric
Infectious Disease link
Selected Recent Publications:
- Rowe JH, Johanns TM, Ertelt JM, Way SS
(2009) CTLA-4 blockade augment the antigen-specific T cell
response after priming with attenuated Listeria monocytogenes
resulting in more rapid clearance of virulent bacterial
challenge. (Immunology,
Epub ahead of print).
- Ertelt JM, Rowe JH, Johanns TM, McLachlan JB, Way
SS (2009) Selective priming and expansion of antigen-specific
Foxp3-CD4+ T cells during Listeria monocytogenens infection.
J
Immunol 182: 3032-3038.
- Curtis MM, Way SS (2009) IL-17 in host
defense against bacterial, mycobacterial, and fungal pathogens.
Immunol
126: 177-185.
- Rowe JH, Johanns TM, Ertelt JM, Way SS
(2008) PDL-1 blockade impedes T cell expansion and protective
immunity primed by attenuated Listeria monocytogenes. J
Immunol 180: 7553-755.
- Orgun, N.N., Mathis, M., Wilson, C.B., Way, S.S. (2008)
Deviation from a Th1 to Th17-dominated CD4 T cell response
in the absence of IL-12 and type-I IFNs sustains protective
CD8 T cells. J.
Immunol. 180:4109-4115.
- Orgun, N.N. and Way, S.S. (2008)
A critical role for phospholipase C in protective immunity
conferred by Listeriolysin O-deficient Listeria monocytogenes.
Microb.
Pathog. 44:159-163.
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Orr, M.T., Orgun, N.N., Wilson, C.B., Way, S.S.
(2007) Cutting Edge: Recombinant Listeria monocytogenes
expressing a single immune-dominant peptide confers protective
immunity to herpes simplex virus-1 infection. J
Immunol 178: 4731-4735.
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Way, S.S., Kolumam, G.A., Havenar-Daughton,
C., Murali-Krishna, K., (2007) IL-12 and type I-IFN synergize
for IFN-g production by CD4 T cells, while neither are
required for IFN-g production by CD8 T cells after Listeria
monocytogenes infection. J
Immunol 178: 4498-4505.
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Kollmann, T.R, Reikie B., Blimkie D, Way, S.S.,
Hajjar, A.M., Arispe, K., Wilson, C.B. (2007) Induction
of Protective immunity to Listeria monocytogenes
in neonates. J
Immunol 178: 3695-3701.
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Way, SS, Wilson, CB(2005)
The Mycobacterium tuberculosis ESAT-6
homologue in Listeria monocytogenes is dispensable
for growth in vitro and in vivo. Infect
Immun 73: 6151-6153.
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Way SS, Wilson CB. (2004) Cutting Edge:
Immunity and IFN-g production during Listeria monocytogenes
infection in the absence of T-bet. J
Immunol 173: 5918-5922.
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Way, S.S., Thompson, L.J., Lopes, J.E.,
Hajjar, A.M., Kollman, T.R., Freitag, N.E., Wilson, C.B.
(2004) Characterization of flagellin expression
and its role in Listeria monocytogenes infection
and immunity. Cell
Microbiol 6: 235-242.
- Way, S.S., Kollman, T.R., Hajjar, A.M.,
Wilson, C.B. (2003) Cutting Edge: Protective cell-mediated
immunity to Listeria monocytogenes in the absence
of Myeloid differentiation factor 88. J
Immunol 171: 533-537.
Last modified on: July 30, 2009
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